Molecular genetics of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) epidemiology and pathogenesis
LA Dourmishev, AL Dourmishev… - Microbiology and …, 2003 - Am Soc Microbiol
Kaposi's sarcoma had been recognized as unique human cancer for a century before it
manifested as an AIDS-defining illness with a suspected infectious etiology. The discovery of …
manifested as an AIDS-defining illness with a suspected infectious etiology. The discovery of …
KSHV LANA—the master regulator of KSHV latency
Kaposi's sarcoma associated herpesvirus (KSHV), like other human herpes viruses,
establishes a biphasic life cycle referred to as dormant or latent, and productive or lytic …
establishes a biphasic life cycle referred to as dormant or latent, and productive or lytic …
The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus supports latent DNA replication in dividing cells
J Hu, AC Garber, R Renne - Journal of virology, 2002 - Am Soc Microbiol
Kaposi's sarcoma-associated herpesvirus (KSHV) is associated with Kaposi's sarcoma,
primary effusion lymphoma, and multicentric Castleman's disease. The latency-associated …
primary effusion lymphoma, and multicentric Castleman's disease. The latency-associated …
Protein interactions targeting the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus to cell chromosomes
A Krithivas, M Fujimuro, M Weidner, DB Young… - Journal of …, 2002 - Am Soc Microbiol
Maintenance of Kaposi's sarcoma-associated herpesvirus (KSHV) latent infection depends
on the viral episomes in the nucleus being distributed to daughter cells following cell …
on the viral episomes in the nucleus being distributed to daughter cells following cell …
Molecular biology of Kaposi's sarcoma-associated herpesvirus and related oncogenesis
Abstract Kaposi's Sarcoma-associated Herpesvirus (KSHV), also known as human
herpesvirus 8 (HHV-8), is the most recently identified human tumor virus, and is associated …
herpesvirus 8 (HHV-8), is the most recently identified human tumor virus, and is associated …
Latency-associated nuclear antigen (LANA) cooperatively binds to two sites within the terminal repeat, and both sites contribute to the ability of LANA to suppress …
AC Garber, J Hu, R Renne - Journal of Biological Chemistry, 2002 - ASBMB
The latency-associated nuclear antigen (LANA) of Kaposi's sarcoma-associated herpesvirus
is a multifunctional protein with important roles in both transcriptional regulation and …
is a multifunctional protein with important roles in both transcriptional regulation and …
ORC, MCM, and histone hyperacetylation at the Kaposi's sarcoma-associated herpesvirus latent replication origin
W Stedman, Z Deng, F Lu, PM Lieberman - Journal of virology, 2004 - Am Soc Microbiol
The viral genome of Kaposi's sarcoma-associated herpesvirus (KSHV) persists as an
extrachromosomal plasmid in latently infected cells. The KSHV latency-associated nuclear …
extrachromosomal plasmid in latently infected cells. The KSHV latency-associated nuclear …
Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus up-regulates transcription of human telomerase reverse transcriptase promoter …
SC Verma, S Borah, ES Robertson - Journal of virology, 2004 - Am Soc Microbiol
Telomerase is required for the maintenance of telomere length and is an important
determinant for cell immortalization. In human cells, telomerase activity is due to the …
determinant for cell immortalization. In human cells, telomerase activity is due to the …
Phase separation and DAXX redistribution contribute to LANA nuclear body and KSHV genome dynamics during latency and reactivation
O Vladimirova, A De Leo, Z Deng, A Wiedmer… - PLoS …, 2021 - journals.plos.org
Liquid-liquid phase separation (LLPS) can drive formation of diverse and essential
macromolecular structures, including those specified by viruses. Kaposi's Sarcoma …
macromolecular structures, including those specified by viruses. Kaposi's Sarcoma …
KSHV LANA inhibits TGF-β signaling through epigenetic silencing of the TGF-β type II receptor
DL Di Bartolo, M Cannon, YF Liu… - Blood, The Journal …, 2008 - ashpublications.org
Signaling through the transforming growth factor–β (TGF-β) pathway results in growth
inhibition and induction of apoptosis in various cell types. We show that this pathway is …
inhibition and induction of apoptosis in various cell types. We show that this pathway is …