Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3,
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …

Glucocorticoids (GCs) are a class of steroid hormones that regulate key physiological
processes such as metabolism, immune function, and stress responses. The effects of GCs …

Dendritic cells (DCs), the most potent antigen-presenting cells, are necessary for effective
activation of naïve T cells. DCs' immunological properties are modulated in response to …

Objectives Giant cell arteritis (GCA) is a complex systemic vasculitis mediated by the
interplay between both genetic and epigenetic factors. Monocytes are crucial players of the …

Ascorbic acid is a redox regulator in many physiological processes. Besides its antioxidant
activity, many intriguing functions of ascorbic acid in the expression of immunoregulatory …

Innate immune cells play essential roles in modulating both immune defense and
inflammation by expressing a diverse array of cytokines and inflammatory mediators …

Monocyte-derived macrophages contribute to pathogenesis in inflammatory diseases and
their effector functions greatly depend on the prevailing extracellular milieu. Whereas M-CSF …

Monocytes can develop an exhausted memory state characterized by reduced
differentiation, pathogenic inflammation, and immune suppression that drives immune …

Objective. Arthritis associated with immune checkpoint inhibitor therapies highlights the
importance of immune checkpoint expression for joint homeostasis. We investigated the role …

Endothelial dysfunction is a crucial factor in promoting organ failure during septic shock.
However, the underlying mechanisms are unknown. Here, we show that kidney injury after …