Simple Summary Patients with glioblastoma—the most frequent and malignant primary brain
tumor—have a poor prognosis with a median survival of less than 15 months. Despite …

Microglia, the resident immune cells in the retina and nervous system, make irreplaceable
contributions to the maintenance of normal homeostasis and immune surveillance of these …

Glioblastoma multiforme (GBM) is the most common and lethal brain tumor characterized by
a strongly immunosuppressive tumor microenvironment (TME) that represents a barrier also …

Brain metastasis still encompass very grim prognosis and therefore understanding the
underlying mechanisms is an urgent need toward developing better therapeutic strategies …

Background Gliomas are one of the most common types of primary tumors in central nervous
system. Previous studies have found that macrophages actively participate in tumor growth …

Glioblastoma (GBM) is a common and highly malignant primary tumor of the central nervous
system in adults. Ever more recent papers are focusing on understanding the role of the …

Diffuse midline glioma (DMG), formerly called diffuse intrinsic pontine glioma (DIPG), is a
high-grade malignant pediatric brain tumor with a near-zero survival rate. To date, only …

Preclinical and clinical antiangiogenic approaches, with multiple side effects such as
resistance, have not been proved to be very successful in treating tumor blood vessels …

The tumor microenvironment is overwhelmingly dictated by macrophages, intimately
affiliated with tumors, exercising pivotal roles in multiple processes, including angiogenesis …

Simple Summary Chemokine signaling is crucial for tumorigenesis, proliferation,
angiogenesis, tumor progression and metastasis in glioblastoma. Furthermore, chemokines …