To study complex biological processes holistically, it is imperative to take an integrative
approach that combines multi-omics data to highlight the interrelationships of the involved …

Cancer is driven by multiple types of genetic alterations, which range in size from point
mutations to whole-chromosome gains and losses, known as aneuploidy. Chromosome …

3-3 proteins are a family of structurally similar phospho-binding proteins that regulate
essentially every major cellular function. Decades of research on 14-3-3s have revealed a …

Cancer is the second largest disease throughout the world with an increasing mortality rate
over the past few years. The patient's survival rate is uncertain due to the limitations of …

The high incidence of aneuploidy in the embryo is considered the principal cause for low
human fecundity. However, the prevalence of aneuploidy dramatically declines as …

Abstract PI3K/AKT signaling leads to reduced apoptosis, stimulates cell growth and
increases proliferation. Under normal conditions, PI3K/AKT activation is tightly controlled …

We present a penalized matrix decomposition (PMD), a new framework for computing a rank-
K approximation for a matrix. We approximate the matrix X as, where dk, uk, and vk minimize …

Determining the genetic basis of cancer requires comprehensive analyses of large
collections of histopathologically well-classified primary tumours. Here we report the results …

Cancer is a complex collection of distinct genetic diseases united by common hallmarks.
Here, we expand upon the classic hallmarks to include the stress phenotypes of …

Recent studies suggest that thousands of genes may contribute to breast cancer
pathophysiologies when deregulated by genomic or epigenomic events. Here, we describe …