The extracellular matrix (ECM) constitutes a highly dynamic three-dimensional structural
network comprised of macromolecules, such as proteoglycans/glycosaminoglycans …

We provide a comprehensive classification of the proteoglycan gene families and respective
protein cores. This updated nomenclature is based on three criteria: Cellular and subcellular …

Cancer metastasis is the dissemination of tumor cells to new sites, resulting in the formation
of secondary tumors. This process is complex and is spatially and temporally regulated by …

Introduction• Perlecan: a pro‐angiogenic proteoglycan• Endorepellin, a C‐terminal fragment
of perlecan with anti‐angiogenic activity• Syndecans in cancer biology• Glypicans and the …

The proteoglycan superfamily now contains more than 30 full-time molecules that fulfill a
variety of biological functions. Proteoglycans act as tissue organizers, influence cell growth …

The extracellular matrix (ECM) consists of numerous macromolecules classified traditionally
into collagens, elastin, and microfibrillar proteins, proteoglycans including hyaluronan, and …

Extracellular matrix is a highly dynamic macromolecular network. Proteoglycans are major
components of extracellular matrix playing key roles in its structural organization and cell …

Perlecan, a large basement membrane heparan sulfate proteoglycan, is expressed in a
wide array of tissues where it regulates diverse cellular processes including bone formation …

Normal tissue function requires adequate supply of oxygen through blood vessels.
Understanding how blood vessels form is a challenging objective because angiogenesis is …

Without new blood vessels, neoplasms cannot expand beyond a few millimeters, the point at
which the diffusion of nutrients and the disposal of waste products become rate-limiting …