Mitochondria are best known for harboring pathways involved in ATP synthesis through the
tricarboxylic acid cycle and oxidative phosphorylation. Major advances in understanding …

The development of clinical interventions that significantly improve human healthspan
requires robust markers of biological age as well as thoughtful therapeutic targets. To …

L-lactate was long considered a glycolytic by-product but is now being recognized as a
signaling molecule involved in cell survival. In this manuscript, we report the role of L-lactate …

Metabolomics is the latest 'omics' technology and systems biology science that allows for
comprehensive profiling of small-molecule metabolites in biological systems at a specific …

Coffee and tea, two of the most popular drinks around the world, share many in common
from chemical components to beneficial effects on human health. One of their shared …

In most organisms, dietary restriction (DR) increases lifespan. However, several studies
have found that genotypes within the same species vary widely in how they respond to DR …

Metabolism plays a significant role in the regulation of aging at different levels, and
metabolic reprogramming represents a major driving force in aging. Metabolic …

Key discoveries in aging research have been made possible with the use of model
organisms. Caenorhabditis elegans is a short-lived nematode that has become a well …

Metformin, the first drug chosen to be tested in a clinical trial aimed to target the biology of
aging per se, has been clinically exploited for decades in the absence of a complete …

The AMP-activated protein kinase (AMPK) and hypoxia-inducible factor (HIF) signaling
pathways are evolutionarily-conserved survival mechanisms responding to two fundamental …