Highlights•Bigels are systems that usually result from mixing a hydrogel and an
organogel.•A hydrophilic biopolymer is commonly the structuring agent of the aqueous …

Oxidative stress and inflammation mostly contribute to aging and age-related conditions
including skin aging. The potential of natural products in the form of naturally-derived …

Background Acne is a common skin disorder that involves an infection inside the hair follicle,
which is usually treated with antibiotics, resulting in unbalanced skin microbiota and …

Bigels are biphasic systems formed by water-based hydrogels and oil-based organogels,
mainly studied, in the last few years, for pharmaceutical and cosmetic application focused on …

Psoriasis is a chronic autoimmune inflammatory disease of the skin that tends to affect
around 2–3% of the global population. As a cascade of events occurs concurrently during …

Despite being one of the most efficacious drugs used in the treatment of basal cell
carcinoma (BCC), imiquimod has limited cutaneous permeation. The current work presents …

Purpose To characterize bigel system as a topical drug delivery vehicle and to establish the
immunomodulatory role of imiquimod-fish oil combination against skin cancer and …

Basal cell carcinoma (BCC) is the most common skin cancer in humans. Topical treatment
with imiquimod provides a non-invasive, self-administered treatment with relatively low …

Purpose: To obtain and evaluate carbopol hydrogel/sorbitan monostearate-almond oil-
based organogel biphasic formulations (bigels) as a semi-solid vehicle for medicated topical …

Although psoriasis remains one of the most devastating inflammatory disorders due to its
huge negative impact on patients' quality of life, new “green” treatment approaches still need …