Background Using a meta-analysis of randomized controlled trials (RCTs), this study aimed
to investigate the efficacy and safety of pemafibrate, a novel selective peroxisome …

Introduction: Significant advancements in the treatment of hypercholesterolemia have
recently been achieved. However, a considerable level of residual cardiovascular risk still …

Hypercholesterolemia is one of the main risk factors for the development of atherosclerosis.
Among the various lipoprotein classes, however, high density lipoproteins (HDL) are …

The endothelium consists of a monolayer of Endothelial Cells (ECs) which form the inner
cellular lining of veins, arteries, capillaries and lymphatic vessels. ECs interact with the …

Endothelium plays an essential role in human homeostasis by regulating arterial blood
pressure, distributing nutrients and hormones as well as providing a smooth surface that …

Gout is a chronic disease associated with deposition of monosodium urate crystals and
accompanied by diabetes, hypertension, and dyslipidemia. Hypertriglyceridemia is common …

Atherosclerosis is a chronic inflammatory disease that is associated with risk of
cardiovascular events. The best-characterised and well-standardised clinical indicator of …

Cardiovascular diseases remain the leading cause of death in the world, and that is why
finding an effective and multi-functional treatment alternative to combat these diseases has …

The knowledge of an inverse relationship between plasma high-density lipoprotein
cholesterol (HDL-C) concentrations and rates of cardiovascular disease has led to the …

Inflammation plays a key role in setting the stage leading to atherosclerosis progression,
and high-sensitivity C-reactive protein (CRP) has been recognized as a predictor of …