Redox modulation of stress resilience by Crocus sativus L. for potential neuroprotective and anti-neuroinflammatory applications in brain disorders: From molecular …

M Scuto, S Modafferi, F Rampulla, V Zimbone… - Mechanisms of Ageing …, 2022 - Elsevier
Recent evidence demonstrates that Crocus sativus L.(saffron) counteracts oxidative stress,
mitochondrial dysfunction and neuroinflammation, closely linked to initiation and …

[HTML][HTML] Turmeric: potential health benefits

K Singletary - Nutrition Today, 2020 - journals.lww.com
For centuries, Curcuma longa (turmeric) was used as a spice in Asian cuisine and as a
medicinal herb for treatment of inflammation, pain, wound healing, and digestive disorders …

Therapeutic effects of high-intensity interval training exercise alone and its combination with ecdysterone against amyloid beta-induced rat model of Alzheimer's …

P Gholipour, A Komaki, H Parsa, M Ramezani - Neurochemical Research, 2022 - Springer
Hippocampal oxidative stress has a vital role in the pathophysiology of Alzheimer's disease
(AD)-associated behavioral deficits. Ecdysterone (Ecdy), a natural product and primary …

Protective role of crocin against sepsis-induced injury in the liver, kidney and lungs via inhibition of p38 MAPK/NF-κB and Bax/Bcl-2 signalling pathways

J Gao, F Zhao, S Yi, S Li, A Zhu, Y Tang… - Pharmaceutical …, 2022 - Taylor & Francis
Context Crocin has been reported to have multiple bioactivities. However, the effect of crocin
administration on caecal ligation and puncture (CLP)-induced sepsis remains unknown …

Therapeutic considerations of bioactive compounds in Alzheimer's disease and Parkinson's disease: Dissecting the molecular pathways

BC Phukan, R Roy, I Gahatraj… - Phytotherapy …, 2023 - Wiley Online Library
Leading neurodegenerative diseases Alzheimer's disease (AD) and Parkinson's disease
(PD) are characterized by the impairment of memory and motor functions, respectively …

Crocin alleviates cognitive impairment associated with atherosclerosis via improving neuroinflammation in LDLR−/− mice fed a high‐fat/cholesterol diet

R Song, S Han, H Gao, H Jiang, X Li - Phytotherapy Research, 2022 - Wiley Online Library
Crocin has been extensively investigated in treating neurodegenerative diseases. However,
its effect on cognitive impairment associated with atherosclerosis remains unknown. The …

[HTML][HTML] Stigma and petals of Crocus sativus L.: Review and comparison of phytochemistry and pharmacology

X Li, J Xie, H Fan, J Tan, D Zhang, Y Bao… - Arabian Journal of …, 2023 - Elsevier
Crocus sativus L.(C. sativus), known as “plant gold”, has numerous functions in traditional
Chinese medicine, including promoting blood circulation, removing blood stasis, cooling …

[HTML][HTML] Protective effects of dendrobium nobile Lindl. Alkaloids on Alzheimer's disease-like symptoms induced by high-methionine diet

T Pi, G Lang, B Liu, J Shi - Current Neuropharmacology, 2022 - ncbi.nlm.nih.gov
Background: High methionine-diet (HMD) causes Alzheimer's disease (AD)-like symptoms.
Previous studies have shown that Dendrobium nobile Lindle. alkaloids (DNLA) have …

Crocin attenuates NLRP3 inflammasome activation by inhibiting mitochondrial reactive oxygen species and ameliorates monosodium urate-induced mouse peritonitis

R Sangare, I Madhi, JH Kim, YH Kim - Current Issues in Molecular …, 2023 - mdpi.com
Crocin is a hydrophilic carotenoid pigment found in the stigma of Crocus sativus or the fruit
of Gardenia jasminoides. In this study, we investigated the effects of Crocin on the activation …

[HTML][HTML] Saffron: Potential health benefits

K Singletary - Nutrition Today, 2020 - journals.lww.com
Saffron is derived from a specific portion of the flowers of Crocus sativus L. and is one of the
most expensive spices in the world. Besides its use in Mediterranean, Middle Eastern, and …