[HTML][HTML] What is the best housing temperature to translate mouse experiments to humans?

J Keijer, M Li, JR Speakman - Molecular metabolism, 2019 - Elsevier
Objectives Ambient temperature impinges on energy metabolism in a body size dependent
manner. This has implications for the housing temperature at which mice are best compared …

Hot dogs: High ambient temperatures impact reproductive success in a tropical carnivore

R Woodroffe, R Groom, JW McNutt - Journal of Animal Ecology, 2017 - Wiley Online Library
Climate change imposes an urgent need to recognise and conserve the species likely to be
worst affected. However, while ecologists have mostly explored indirect effects of rising …

Late lactation in small mammals is a critically sensitive window of vulnerability to elevated ambient temperature

ZJ Zhao, C Hambly, LL Shi, ZQ Bi… - Proceedings of the …, 2020 - National Acad Sciences
Predicted increases in global average temperature are physiologically trivial for most
endotherms. However, heat waves will also increase in both frequency and severity, and …

Switching off the furnace: brown adipose tissue and lactation

E Król, JR Speakman - Molecular Aspects of Medicine, 2019 - Elsevier
In rodents, brown adipose tissue (BAT) is dynamically regulated by reproductive state, with
greater thermogenic activity and capacity outside reproduction and subsequent …

[HTML][HTML] The long-lasting shadow of litter size in rodents: litter size is an underreported variable that strongly determines adult physiology

M Parra-Vargas, SG Bouret, JC Bruning… - Molecular …, 2023 - Elsevier
Abstract Background/Purpose Litter size is a biological variable that strongly influences adult
physiology in rodents. Despite evidence from previous decades and recent studies …

Exposure to hot temperatures during lactation in Swiss mice stunts offspring growth and decreases future reproductive performance of female offspring

MH Bao, LB Chen, C Hambly… - Journal of …, 2020 - journals.biologists.com
Exposure to high temperatures (heatwaves) is rapidly emerging as an important issue of
climate change, in particular for female mammals during lactation. High temperatures …

Setting ambient temperature conditions to optimize translation of molecular work from the mouse to human: the “Goldilocks Solution”

M Li, JR Speakman - Brown Adipose Tissue: Methods and Protocols, 2022 - Springer
Temperature has a profound effect on many aspects of murine physiology. This raises the
question of the best temperature at which mice should be housed to maximize the …

Sustained energy intake in lactating Swiss mice: a dual modulation process

J Wen, S Tan, QG Qiao, WJ Fan… - Journal of …, 2017 - journals.biologists.com
Limits to sustained energy intake (SusEI) during lactation are important because they
provide an upper boundary below which females must trade off competing physiological …

Limits to sustained energy intake. XXXIII. Thyroid hormones play important roles in milk production but do not define the heat dissipation limit in Swiss mice

R Yang, J Cao, JR Speakman… - Journal of Experimental …, 2023 - journals.biologists.com
The limits to sustained energy intake set physiological upper boundaries that affect many
aspects of human and animal performance. The mechanisms underlying these limits …

[HTML][HTML] Effect of different ambient temperatures on reproductive outcome and stress level of lactating females in two mouse strains

T Kolbe, C Lassnig, A Poelzl, R Palme, KE Auer… - Animals, 2022 - mdpi.com
Simple Summary The optimal temperature for laboratory mice has been under discussion for
some time. Current standard temperature is 20° C–24° C but it has been suggested to …