Therapeutics targeting drivers of thoracic aortic aneurysms and acute aortic dissections: insights from predisposing genes and mouse models

DM Milewicz, SK Prakash… - Annual review of medicine, 2017 - annualreviews.org
Thoracic aortic diseases, including aneurysms and dissections of the thoracic aorta, are a
major cause of morbidity and mortality. Risk factors for thoracic aortic disease include …

[HTML][HTML] Evolution of surgical therapy for Stanford acute type A aortic dissection

P Chiu, DC Miller - Annals of cardiothoracic surgery, 2016 - ncbi.nlm.nih.gov
Acute type A aortic dissection (AcA-AoD) is a surgical emergency associated with very high
morbidity and mortality. Unfortunately, the early outcome of emergency surgical repair has …

JCS/JSCVS/JATS/JSVS 2020 guideline on diagnosis and treatment of aortic aneurysm and aortic dissection

H Ogino, O Iida, K Akutsu, Y Chiba, H Hayashi… - Circulation …, 2023 - jstage.jst.go.jp
Of the clinical practice guideline of the Japanese Circulation Society concerning aortic
diseases, the Guidelines on Diagnosis and Treatment of Aortic Dissection (first edition) were …

[HTML][HTML] Reimplantation of the aortic valve at 20 years

TE David, CM David, CM Feindel, C Manlhiot - The Journal of thoracic and …, 2017 - Elsevier
Objective To provide additional information on clinical and echocardiographic outcomes
after reimplantation of the aortic valve (RAV) in patients with aortic root aneurysm. Methods …

Valve-sparing root replacement compared with composite valve graft procedures in patients with aortic root dilation

M Ouzounian, V Rao, C Manlhiot, N Abraham… - Journal of the American …, 2016 - jacc.org
Background: Although aortic valve-sparing (AVS) operations are established alternatives to
composite valve graft (CVG) procedures for patients with aortic root aneurysms, comparative …

Aortic valve sparing in different aortic valve and aortic root conditions

TE David - Journal of the American College of Cardiology, 2016 - jacc.org
The development of aortic valve-sparing operations (reimplantation of the aortic valve and
remodeling of the aortic root) expanded the surgical armamentarium for treating patients …

Outcomes of valve-sparing surgery in heritable aortic disorders: results from the AVIATOR registry

V Chauvette, J Kluin, L de Kerchove… - European journal of …, 2022 - academic.oup.com
OBJECTIVES Root reimplantation has been the favoured approach for patients with
heritable aortic disorder requiring valve-sparring root replacement. In the past few years …

Aortic dissection: medical, interventional and surgical management

M Silaschi, J Byrne, O Wendler - Heart, 2017 - heart.bmj.com
Acute aortic dissection (AAD) is a relatively rare but much-feared clinical presentation which
has a high mortality, particularly if definitive treatment is delayed. A combination of aortic …

Marfan syndrome

DM Milewicz, AC Braverman, J De Backer… - Nature reviews Disease …, 2021 - nature.com
Marfan syndrome (MFS) is an autosomal dominant, age-related but highly penetrant
condition with substantial intrafamilial and interfamilial variability. MFS is caused by …

[HTML][HTML] Systematic review and meta-analysis of surgical outcomes in Marfan patients undergoing aortic root surgery by composite-valve graft or valve sparing root …

CD Flynn, DH Tian, A Wilson-Smith… - Annals of …, 2017 - ncbi.nlm.nih.gov
Background A major, life-limiting feature of Marfan syndrome (MFS) is the presence of
aneurysmal disease. Cardiovascular intervention has dramatically improved the life …