Protein O-GlcNAcylation: emerging mechanisms and functions
O-GlcNAcylation—the attachment of O-linked N-acetylglucosamine (O-GlcNAc) moieties to
cytoplasmic, nuclear and mitochondrial proteins—is a post-translational modification that …
cytoplasmic, nuclear and mitochondrial proteins—is a post-translational modification that …
Nutrient regulation of signaling and transcription
GW Hart - Journal of Biological Chemistry, 2019 - ASBMB
In the early 1980s, while using purified glycosyltransferases to probe glycan structures on
surfaces of living cells in the murine immune system, we discovered a novel form of …
surfaces of living cells in the murine immune system, we discovered a novel form of …
Glucose metabolism in cardiac hypertrophy and heart failure
Heart failure is one of the leading causes of death worldwide and has been singled out as
an emerging epidemic. 1, 2 With a 5-year survival rate of 50%, heart failure poses a …
an emerging epidemic. 1, 2 With a 5-year survival rate of 50%, heart failure poses a …
Metabolic coordination of physiological and pathological cardiac remodeling
Metabolic pathways integrate to support tissue homeostasis and to prompt changes in cell
phenotype. In particular, the heart consumes relatively large amounts of substrate not only to …
phenotype. In particular, the heart consumes relatively large amounts of substrate not only to …
Role of O-linked N-acetylglucosamine protein modification in cellular (patho)physiology
In the mid-1980s, the identification of serine and threonine residues on nuclear and
cytoplasmic proteins modified by a N-acetylglucosamine moiety (O-GlcNAc) via an O …
cytoplasmic proteins modified by a N-acetylglucosamine moiety (O-GlcNAc) via an O …
Mitochondrial VDAC1: a key gatekeeper as potential therapeutic target
AKS Camara, YF Zhou, PC Wen, E Tajkhorshid… - Frontiers in …, 2017 - frontiersin.org
Mitochondria are the key source of ATP that fuels cellular functions, and they are also central
in cellular signaling, cell division and apoptosis. Dysfunction of mitochondria has been …
in cellular signaling, cell division and apoptosis. Dysfunction of mitochondria has been …
An overview of the molecular mechanisms associated with myocardial ischemic injury: state of the art and translational perspectives
L Schirone, M Forte, L D'Ambrosio, V Valenti… - Cells, 2022 - mdpi.com
Cardiovascular disease is the leading cause of death in western countries. Among
cardiovascular diseases, myocardial infarction represents a life-threatening condition …
cardiovascular diseases, myocardial infarction represents a life-threatening condition …
Diabetic cardiomyopathy: mechanisms and new treatment strategies targeting antioxidant signaling pathways
K Huynh, BC Bernardo, JR McMullen… - Pharmacology & …, 2014 - Elsevier
Cardiovascular disease is the primary cause of morbidity and mortality among the diabetic
population. Both experimental and clinical evidence suggest that diabetic subjects are …
population. Both experimental and clinical evidence suggest that diabetic subjects are …
Cross talk between O-GlcNAcylation and phosphorylation: roles in signaling, transcription, and chronic disease
O-GlcNAcylation is the addition of β-DN-acetylglucosamine to serine or threonine residues
of nuclear and cytoplasmic proteins. O-linked N-acetylglucosamine (O-GlcNAc) was not …
of nuclear and cytoplasmic proteins. O-linked N-acetylglucosamine (O-GlcNAc) was not …
[HTML][HTML] Spliced X-box binding protein 1 couples the unfolded protein response to hexosamine biosynthetic pathway
The hexosamine biosynthetic pathway (HBP) generates uridine diphosphate N-
acetylglucosamine (UDP-GlcNAc) for glycan synthesis and O-linked GlcNAc (O-GlcNAc) …
acetylglucosamine (UDP-GlcNAc) for glycan synthesis and O-linked GlcNAc (O-GlcNAc) …