Research into the mechanisms and manifestations of solid tumor vascularization was
launched more than 50 years ago with the proposition and experimental demonstrations that …

Angiogenesis is a significant event in a wide range of healthy and diseased conditions. This
process frequently involves vasodilation and an increase in vascular permeability …

After a quarter century of rapid advances, cancer research has generated a rich and
complex body of knowledge, revealing cancer to be a disease involving dynamic changes in …

The family of fibroblast growth factors (FGFs) regulates a plethora of developmental
processes, including brain patterning, branching morphogenesis and limb development …

Vascular disrupting agents such as 5, 6-dimethylxanthenone-4-acetic acid (DMXAA)
represent a novel approach for cancer treatment. DMXAA has potent antitumor activity in …

Fibroblast growth factors (FGFs) are a family of heparin-binding growth factors. FGFs exert
their pro-angiogenic activity by interacting with various endothelial cell surface receptors …

Angiogenesis is a complex process depending on the coordination of many regulators and
there by activating angiogenic switch. Recent advances in understanding of angiogenic …

Angiogenesis is fundamental to reproduction, development, and repair. All these processes
depend on the tightly regulated growth of blood vessels that can “turn on” and “turn off” …

Angiogenesis, the recruitment of new blood vessels, is an essential component of the
metastatic pathway. These vessels provide the principal route by which tumor cells exit the …

Angiogenesis inhibitors are a new class of drugs, for which the general rules involving
conventional chemotherapy might not apply. The successful translation of angiogenesis …