Attacking the PI3K/Akt/mTOR signaling pathway for targeted therapeutic treatment in human cancer
Cancer is the second leading cause of human death globally. PI3K/Akt/mTOR signaling is
one of the most frequently dysregulated signaling pathways observed in cancer patients that …
one of the most frequently dysregulated signaling pathways observed in cancer patients that …
Liver cancer cell of origin, molecular class, and effects on patient prognosis
Primary liver cancer is the second leading cause of cancer-related death worldwide and
therefore a major public health challenge. We review hypotheses of the cell of origin of liver …
therefore a major public health challenge. We review hypotheses of the cell of origin of liver …
Prospective genotyping of hepatocellular carcinoma: clinical implications of next-generation sequencing for matching patients to targeted and immune therapies
Purpose: Prior molecular profiling of hepatocellular carcinoma (HCC) has identified
actionable findings that may have a role in guiding therapeutic decision-making and clinical …
actionable findings that may have a role in guiding therapeutic decision-making and clinical …
Role of the mammalian target of rapamycin pathway in liver cancer: from molecular genetics to targeted therapies
X Lu, P Paliogiannis, DF Calvisi, X Chen - Hepatology, 2021 - Wiley Online Library
Primary liver cancers, including hepatocellular carcinoma (HCC) and intrahepatic
cholangiocarcinoma (iCCA), are highly lethal tumors, with high worldwide frequency and …
cholangiocarcinoma (iCCA), are highly lethal tumors, with high worldwide frequency and …
[HTML][HTML] Metabolic reprogramming in cancer cells: emerging molecular mechanisms and novel therapeutic approaches
The constant changes in cancer cell bioenergetics are widely known as metabolic
reprogramming. Reprogramming is a process mediated by multiple factors, including …
reprogramming. Reprogramming is a process mediated by multiple factors, including …
Infection and cancer: the case of hepatitis B
Infection is a well-described cause of cancer in humans. Being one of the most common
infections worldwide, hepatitis B virus (HBV) is the leading cause of hepatocellular …
infections worldwide, hepatitis B virus (HBV) is the leading cause of hepatocellular …
mTORC1/2 inhibition preserves ovarian function and fertility during genotoxic chemotherapy
KN Goldman, D Chenette, R Arju… - Proceedings of the …, 2017 - National Acad Sciences
The ovary contains oocytes within immature (primordial) follicles that are fixed in number at
birth. Activation of follicles within this fixed pool causes an irreversible decline in …
birth. Activation of follicles within this fixed pool causes an irreversible decline in …
[HTML][HTML] Inhibiting glutamine-dependent mTORC1 activation ameliorates liver cancers driven by β-catenin mutations
AOA Michael, S Ko, J Tao, A Moghe, H Yang, M Xu… - Cell metabolism, 2019 - cell.com
Based on their lobule location, hepatocytes display differential gene expression, including
pericentral hepatocytes that surround the central vein, which are marked by Wnt-β-catenin …
pericentral hepatocytes that surround the central vein, which are marked by Wnt-β-catenin …
[HTML][HTML] mTOR cross-talk in cancer and potential for combination therapy
F Conciatori, L Ciuffreda, C Bazzichetto, I Falcone… - Cancers, 2018 - mdpi.com
The mammalian Target of Rapamycin (mTOR) pathway plays an essential role in sensing
and integrating a variety of exogenous cues to regulate cellular growth and metabolism, in …
and integrating a variety of exogenous cues to regulate cellular growth and metabolism, in …
[HTML][HTML] Tuberous sclerosis complex
H Northrup, MK Koenig, DA Pearson, KS Au - 2021 - europepmc.org
Tuberous sclerosis complex (TSC) involves abnormalities of the skin (hypomelanotic
macules, confetti skin lesions, facial angiofibromas, shagreen patches, fibrous cephalic …
macules, confetti skin lesions, facial angiofibromas, shagreen patches, fibrous cephalic …