Senescent cells release a variety of cytokines, proteases, and growth factors collectively
known as the senescence-associated secretory phenotype (SASP). Sustained SASP …

Acute kidney injury (AKI) accompanies with high morbidity and mortality. Incomplete renal
recovery can lead to chronic and finally end-stage kidney disease, which results in the …

Background. Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common upper airway
inflammatory disease with a high postoperative recurrence rate. This study is aimed at …

Both acute and chronic antibody-mediated allograft rejection (AMR), which are directly
mediated by B cells, remain difficult to treat. Long-lived plasma cells (LLPCs) in bone …

Antibody-mediated rejection (AMR) can cause graft failure following renal transplantation.
Neutrophils play a key role in AMR progression, but the exact mechanism remains unclear …

Attaining a fair long-term allograft survival remains a challenge for allogeneic transplantation
worldwide. Although the emergence of immunosuppressants has caused noticeable …

BAFF system plays an essential role in B cells homeostasis and tolerance, although it has
widely not been tested in transplantation with doubtful results. The main purpose was to …

Abstract Cytokines from the Tumour Necrosis Factor (TNF) family are important regulators of
both physiological and pathological processes. The discovery of novel TNF ligands and …

B cell-activating factor (BAFF) can bind with specific receptors to activate signalling
pathways associated with the B cell activation. Belimumab and tabalumab are anti-BAFF (B …