Mechanism of action of ribosomally synthesized and post-translationally modified peptides

C Ongpipattanakul, EK Desormeaux… - Chemical …, 2022 - ACS Publications
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a natural
product class that has undergone significant expansion due to the rapid growth in genome …

New developments in RiPP discovery, enzymology and engineering

M Montalbán-López, TA Scott, S Ramesh… - Natural product …, 2021 - pubs.rsc.org
Covering: up to June 2020 Ribosomally-synthesized and post-translationally modified
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …

The manifold roles of microbial ribosomal peptide–based natural products in physiology and ecology

Y Li, S Rebuffat - Journal of Biological Chemistry, 2020 - ASBMB
The ribosomally synthesized and posttranslationally modified peptides (RiPPs), also called
ribosomal peptide natural products (RPNPs), form a growing superfamily of natural products …

Bicyclostreptins are radical SAM enzyme-modified peptides with unique cyclization motifs

LB Bushin, BC Covington, KA Clark, A Caruso… - Nature Chemical …, 2022 - nature.com
Microbial natural products comprise diverse architectures that are generated by equally
diverse biosynthetic strategies. In peptide natural products, amino acid sidechains are …

A mycofactocin-associated dehydrogenase is essential for ethylene glycol metabolism by Rhodococcus jostii RHA1

T Shimizu, K Suzuki, M Inui - Applied Microbiology and Biotechnology, 2024 - Springer
Ethylene glycol is an industrially important diol in many manufacturing processes and a
building block of polymers, such as poly (ethylene terephthalate). In this study, we found that …

How a subfamily of radical S-adenosylmethionine enzymes became a mainstay of ribosomally synthesized and post-translationally modified peptide discovery

A Mendauletova, A Kostenko, Y Lien… - ACS bio & med Chem …, 2021 - ACS Publications
Radical S-adenosylmethionine (rSAM) enzymes are a large and diverse superfamily of
enzymes, some of which are known to participate in the biosynthesis of ribosomally …

Opportunities and challenges of RiPP-based therapeutics

IPM Pfeiffer, MP Schröder, S Mordhorst - Natural Product Reports, 2024 - pubs.rsc.org
Covering: up to 2024Ribosomally synthesised and post-translationally modified peptides
(RiPPs) comprise a substantial group of peptide natural products exhibiting noteworthy …

Radical SAM Enzymes and Ribosomally‐Synthesized and Post‐translationally Modified Peptides: A Growing Importance in the Microbiomes

A Benjdia, O Berteau - Frontiers in Chemistry, 2021 - frontiersin.org
To face the current antibiotic resistance crisis, novel strategies are urgently required. Indeed,
in the last 30 years, despite considerable efforts involving notably high-throughput screening …

Genome Mining for New Enzyme Chemistry

DT Nguyen, DA Mitchell, WA van der Donk - ACS catalysis, 2024 - ACS Publications
A revolution in the field of biocatalysis has enabled scalable access to compounds of high
societal values using enzymes. The construction of biocatalytic routes relies on the reservoir …

Metabolic profiling of dormant Mycolicibacterium smegmatis cells' reactivation reveals a gradual assembly of metabolic processes

VD Nikitushkin, S Trenkamp, GR Demina, MO Shleeva… - Metabolomics, 2020 - Springer
Introduction Under gradual acidification of the culture medium mycobacterial cells transit into
a specific state characterized by low level of metabolic activity and morphological …