Natural killer cells: a promising immunotherapy for cancer

J Chu, F Gao, M Yan, S Zhao, Z Yan, B Shi… - Journal of translational …, 2022 - Springer
As a promising alternative platform for cellular immunotherapy, natural killer cells (NK) have
recently gained attention as an important type of innate immune regulatory cell. NK cells can …

Uterine natural killer cells: functional distinctions and influence on pregnancy in humans and mice

LM Gaynor, F Colucci - Frontiers in immunology, 2017 - frontiersin.org
Our understanding of development and function of natural killer (NK) cells has progressed
significantly in recent years. However, exactly how uterine NK (uNK) cells develop and …

NK cell education via nonclassical MHC and non-MHC ligands

Y He, Z Tian - Cellular & molecular immunology, 2017 - nature.com
Natural killer (NK) cell education, a process for achieving functional maturation and self-
tolerance, has been previously defined by the interaction between self-major …

Clinical utility of natural killer cells in cancer therapy and transplantation

DA Knorr, V Bachanova, MR Verneris, JS Miller - Seminars in immunology, 2014 - Elsevier
Natural killer (NK) cells recognize deranged cells that display stress receptors or loss of
major histocompatibility complex (MHC) class I. During development, NK cells become …

SHP-1-mediated inhibitory signals promote responsiveness and anti-tumour functions of natural killer cells

C Viant, A Fenis, G Chicanne, B Payrastre… - Nature …, 2014 - nature.com
Natural killer (NK) cells are cytotoxic innate lymphoid cells that are involved in immune
defense. NK cell reactivity is controlled in part by MHC class I recognition by inhibitory …

Natural killer cells in inflammatory autoimmune diseases

Y Yang, J Day… - Clinical & …, 2021 - Wiley Online Library
Natural killer (NK) cells are a specialised population of innate lymphoid cells (ILCs) that help
control local immune responses. Through natural cytotoxicity, production of cytokines and …

Dynamic variability in SHP-1 abundance determines natural killer cell responsiveness

Z Wu, S Park, CM Lau, Y Zhong, S Sheppard… - Science …, 2021 - science.org
Interactions between human leukocyte antigen (HLA) molecules on target cells and the
inhibitory killer cell immunoglobulin-like receptors (KIRs) and heterodimeric inhibitory …

NK cells: An attractive candidate for cancer therapy

B Valipour, K Velaei, A Abedelahi… - Journal of cellular …, 2019 - Wiley Online Library
Natural killer (NK) cells have significant capability in tumor immune‐surveillance. The ability
of lyse transformed cells immediately in an antigen‐independent manner make them an …

NK cells shape pancreatic and oral tumor microenvironments; role in inhibition of tumor growth and metastasis

A Jewett, J Kos, Y Fong, MW Ko, T Safaei… - Seminars in cancer …, 2018 - Elsevier
We have recently shown that natural killer (NK) cells select and differentiate cancer stem
cells (CSCs)/undifferentiated tumors via secreted and membrane bound IFN-gamma (IFN-γ) …

Education-dependent activation of glycolysis promotes the cytolytic potency of licensed human natural killer cells

JR Schafer, TC Salzillo, N Chakravarti… - Journal of Allergy and …, 2019 - Elsevier
Background The mechanism by which natural killer (NK) cell education results in licensed
NK cells with heightened effector function against missing self-targets is not known …