Pre-eclampsia
Pre-eclampsia is a life-threatening disease of pregnancy unique to humans and a leading
cause of maternal and neonatal morbidity and mortality. Women who survive pre-eclampsia …
cause of maternal and neonatal morbidity and mortality. Women who survive pre-eclampsia …
[HTML][HTML] Therapeutic potential of targeting galectins–A biomaterials-focused perspective
Among all the biological entities involved in the immune response, galectins, a family of
glycan-binding proteins, have been described as key in immune cell homeostasis and …
glycan-binding proteins, have been described as key in immune cell homeostasis and …
Extracellular vesicles derived from Akkermansia muciniphila promote placentation and mitigate preeclampsia in a mouse model
Y Chen, Z Ou, M Pang, Z Tao, X Zheng… - Journal of …, 2023 - Wiley Online Library
Preeclampsia (PE) is a multisystem disorder with high maternal morbidity and mortality
rates. Currently, no practical therapeutic approach is available to prevent PE progression …
rates. Currently, no practical therapeutic approach is available to prevent PE progression …
Medawar's PostEra: galectins emerged as key players during fetal-maternal glycoimmune adaptation
E Menkhorst, NG Than, U Jeschke… - Frontiers in …, 2021 - frontiersin.org
Lectin-glycan interactions, in particular those mediated by the galectin family, regulate many
processes required for a successful pregnancy. Over the past decades, increasing evidence …
processes required for a successful pregnancy. Over the past decades, increasing evidence …
Galectin functions in cancer-associated inflammation and thrombosis
L Kruk, A Braun, E Cosset, T Gudermann… - Frontiers in …, 2023 - frontiersin.org
Galectins are carbohydrate-binding proteins that regulate many cellular functions including
proliferation, adhesion, migration, and phagocytosis. Increasing experimental and clinical …
proliferation, adhesion, migration, and phagocytosis. Increasing experimental and clinical …
Functions and inhibition of galectin-7, an emerging target in cellular pathophysiology
NV Sewgobind, S Albers, RJ Pieters - Biomolecules, 2021 - mdpi.com
Galectin-7 is a soluble unglycosylated lectin that is able to bind specifically to β-
galactosides. It has been described to be involved in apoptosis, proliferation and …
galactosides. It has been described to be involved in apoptosis, proliferation and …
Galectins: important regulators in normal and pathologic pregnancies
M Chen, JL Shi, ZM Zheng, Z Lin, MQ Li… - International Journal of …, 2022 - mdpi.com
Galectins (Gal) are characterized by their affinity for galactoside structures on
glycoconjugates. This relationship is mediated by carbohydrate recognition domains, which …
glycoconjugates. This relationship is mediated by carbohydrate recognition domains, which …
Galectins in early pregnancy and pregnancy-associated pathologies
M Jovanović Krivokuća, A Vilotić… - International Journal of …, 2021 - mdpi.com
Galectins are a family of conserved soluble proteins defined by an affinity for β-galactoside
structures present on various glycoconjugates. Over the past few decades, galectins have …
structures present on various glycoconjugates. Over the past few decades, galectins have …
Melatonin regulates trophoblast pyroptosis, invasion and migration in preeclampsia by inhibiting HtrA1 transcription through the microRNA‐520c‐3p/SETD7 axis
Z Liu, B Chen, J Chang, L Feng… - American Journal of …, 2022 - Wiley Online Library
Objective Melatonin has an inhibitory effect on preeclampsia (PE). This study was launched
to explore the way that melatonin regulated trophoblast migration, invasion, and pyroptosis …
to explore the way that melatonin regulated trophoblast migration, invasion, and pyroptosis …
Fetal growth restriction induced by maternal gal-3 deficiency is associated with altered gut-placenta axis
Y Xie, F Zhao, Y Wang, S Borowski, N Freitag… - Cell death & …, 2024 - nature.com
Adverse intrauterine conditions may cause fetal growth restriction (FGR), a pregnancy
complication frequently linked to perinatal morbidity and mortality. Although many studies …
complication frequently linked to perinatal morbidity and mortality. Although many studies …