Wound healing impairment represents a particularly challenging clinical problem to which
no efficacious treatment regimens currently exist. The factors ensuring appropriate …

Wound healing involves platelets, inflammatory cells, fibroblasts, and epithelial cells. All of
these cell types are capable of producing nitric oxide (NO), either constitutively or in …

Arginine is a basic amino acid that plays several pivotal roles in cellular physiology. Like any
amino acid, it is involved with protein synthesis, but it is also intimately involved with cell …

Modern advances in nutritional therapies have led to the specific use of arginine
supplementation for protein synthesis, cell signaling through the production of nitric oxide …

Diabetes impairs wound healing and there are few therapeutic options to reverse it.
Previous work has demonstrated the importance of nitric oxide for successful wound …

l-Arginine is one of the most metabolically versatile amino acids. In addition to its role in the
synthesis of nitric oxide, l-arginine serves as a precursor for the synthesis of polyamines …

Despite an improved understanding of pelvic anatomy and organ function and advances in
surgical techniques, long-term success rates in pelvic surgery are still variable (3-59%), but …

Arginine supplementation has been identified as advantageous in experimental wound
healing. However, the mechanisms underlying this beneficial effect in tissue repair remain …

Nitric oxide (NO) is synthesized from a guanidino nitrogen of L-arginine by one of three nitric
oxide synthase (NOS) enzymes, each with distinct subcellular and cellular location, amino …

Since its discovery in 1987, many biological roles (including wound healing) have been
identified for nitric oxide (NO). The gas is produced by NO synthase using the dibasic amino …