The prevailing view of metazoan gene regulation is that transcription is facilitated through
the formation of static activator complexes at distal regulatory regions. Here, we employed …

Enhancers are noncoding regulatory elements that instruct spatial and temporal specificity of
gene transcription in response to a variety of intrinsic and extrinsic signals during …

While the accessibility of enhancers is dynamically regulated during development,
promoters tend to be constitutively accessible and poised for activation by paused Pol II. By …

Highlights•Technical innovations allow live imaging of transcriptional dynamics in
embryos.•Digging deeper brought new insights into Drosophila gene regulation and …

Transcription often occurs in bursts as gene promoters switch stochastically between active
and inactive states. Enhancers can dictate transcriptional activity in animal development …

Rapid enhancer and slow promoter evolution have been demonstrated through comparative
genomics. However, it is not clear how this information is encoded genetically and if this can …

Non-coding transcription at the intergenic regulatory regions is a prevalent feature of
metazoan genomes, but its biological function remains uncertain. Here, we devise a live …

The study characterized the transcriptionally regulatory mechanism and functions of three
zinc (Zn) transporters (znt4, znt5 and znt10) in Zn 2+ metabolism in yellow catfish …

Introduction Super-enhancers (SEs) are clusters of enhancers that act synergistically to drive
the high-level expression of genes involved in cell identity and function. Although SEs have …

Proper enhancer–promoter interactions are essential to maintaining specific transcriptional
patterns and preventing ectopic gene expression. Drosophila is an ideal model organism to …