Medicinal chemistry of indole derivatives: Current to future therapeutic prospectives

A Kumari, RK Singh - Bioorganic chemistry, 2019 - Elsevier
Indole is a versatile pharmacophore, a privileged scaffold and an outstanding heterocyclic
compound with wide ranges of pharmacological activities due to different mechanisms of …

A review on diverse heterocyclic compounds as the privileged scaffolds in antimalarial drug discovery

PN Kalaria, SC Karad, DK Raval - European journal of medicinal chemistry, 2018 - Elsevier
The upward extend of malaria collectively with the emergence of resistance against
predictable drugs has put enormous pressure on public health systems to introduce new …

An insight into the medicinal perspective of synthetic analogs of indole: A review

PV Thanikachalam, RK Maurya, V Garg… - European journal of …, 2019 - Elsevier
Heterocycles occupy a salient place in chemistry due to their wide range of activity in the
fields of drug design, photochemistry, agrochemicals, dyes, and so on. Amongst all, indole …

Recent progress in biological activities of indole and indole alkaloids

TP Singh, OM Singh - Mini reviews in medicinal chemistry, 2018 - ingentaconnect.com
The indole scaffold is found in a wide range of bioactive heterocycles and natural products.
Moreover, the indole moiety is considered as the active principle in several alkaloids such …

[HTML][HTML] A brief review of the biological potential of indole derivatives

S Kumar, Ritika - Future Journal of Pharmaceutical Sciences, 2020 - Springer
Background Various bioactive aromatic compounds containing the indole nucleus showed
clinical and biological applications. Indole scaffold has been found in many of the important …

Sustainable flow approaches to active pharmaceutical ingredients

F Ferlin, D Lanari, L Vaccaro - Green Chemistry, 2020 - pubs.rsc.org
The adoption of flow conditions has been the object of growing attention from both academia
and industry. The shift from batch to continuous-flow technology is very stimulating from a …

An insight into the recent developments in anti-infective potential of indole and associated hybrids

BS Mathada, SB Somappa - Journal of Molecular Structure, 2022 - Elsevier
Prevention, accurate diagnosis, and effective treatment of infections are the main challenges
in the overall management of infectious diseases. The best example is the ongoing SARs …

[HTML][HTML] Flow-based enzymatic synthesis of melatonin and other high value tryptamine derivatives: A five-minute intensified process

ML Contente, S Farris, L Tamborini, F Molinari… - Green chemistry, 2019 - pubs.rsc.org
To increase the uptake of biocatalytic processes by industry, it is essential to demonstrate
the reliability of enzyme-based methodologies directly applied to the production of high …

[HTML][HTML] Recent progress in the development of indole-based compounds active against malaria, trypanosomiasis and leishmaniasis

PAF Pacheco, MMM Santos - Molecules, 2022 - mdpi.com
Human protozoan diseases represent a serious health problem worldwide, affecting mainly
people in social and economic vulnerability. These diseases have attracted little investment …

Indole-based melatonin analogues: Synthetic approaches and biological activity

SY Wang, XC Shi, P Laborda - European Journal of Medicinal Chemistry, 2020 - Elsevier
Melatonin is a natural hormone primarily released by the pineal gland that regulates the
sleep-wake cycles. The diverse biological applications of melatonin, together with the need …