Basic methods of cell cycle analysis

A Ligasová, I Frydrych, K Koberna - International Journal of Molecular …, 2023 - mdpi.com
Cellular growth and the preparation of cells for division between two successive cell
divisions is called the cell cycle. The cell cycle is divided into several phases; the length of …

Architecture of the cytoplasmic face of the nuclear pore

CJ Bley, S Nie, GW Mobbs, S Petrovic, AT Gres, X Liu… - Science, 2022 - science.org
INTRODUCTION Cytoplasmic face of the human NPC. Near-atomic composite structure of
the NPC generated by docking high-resolution crystal structures into a cryo‑ET …

The palette of techniques for cell cycle analysis

AE Eastman, S Guo - FEBS letters, 2020 - Wiley Online Library
The cell division cycle is the generational period of cellular growth and propagation. Cell
cycle progression needs to be highly regulated to preserve genomic fidelity while increasing …

High-resolution Repli-Seq defines the temporal choreography of initiation, elongation and termination of replication in mammalian cells

PA Zhao, T Sasaki, DM Gilbert - Genome biology, 2020 - Springer
Background DNA replication in mammalian cells occurs in a defined temporal order during
S phase, known as the replication timing (RT) programme. Replication timing is …

CD44+ and CD133+ non-small cell lung cancer cells exhibit DNA damage response pathways and dormant polyploid giant cancer cell enrichment relating to their p53 …

M Pustovalova, T Blokhina, L Alhaddad… - International Journal of …, 2022 - mdpi.com
Cancer stem cells (CSCs) play a critical role in the initiation, progression and therapy
relapse of many cancers including non-small cell lung cancer (NSCLC). Here, we aimed to …

BRG1 loss predisposes lung cancers to replicative stress and ATR dependency

M Gupta, CP Concepcion, CG Fahey, H Keshishian… - Cancer research, 2020 - AACR
Abstract Inactivation of SMARCA4/BRG1, the core ATPase subunit of mammalian SWI/SNF
complexes, occurs at very high frequencies in non–small cell lung cancers (NSCLC). There …

Scutellarein inhibits BLM-mediated pulmonary fibrosis by affecting fibroblast differentiation, proliferation, and apoptosis

K Miao, T Pan, Y Mou, L Zhang… - … in Chronic Disease, 2020 - journals.sagepub.com
Introduction: Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible interstitial
pulmonary disease that has a poor prognosis. Scutellarein, which is extracted from the …

Berberine inhibits telomerase activity and induces cell cycle arrest and telomere erosion in colorectal cancer cell line, HCT 116

MA Samad, MZ Saiman, N Abdul Majid, SA Karsani… - Molecules, 2021 - mdpi.com
Colorectal cancer (CRC) is the most common cancer among males and females, which is
associated with the increment of telomerase level and activity. Some plant-derived …

Trypanosoma cruzi amastigotes that persist in the colon during chronic stage murine infections have a reduced replication rate

AI Ward, F Olmo, RL Atherton, MC Taylor… - Open …, 2020 - royalsocietypublishing.org
Chronic Trypanosoma cruzi infections are typically lifelong, with small numbers of parasites
surviving in restricted tissue sites, which include the gastrointestinal tract. There is …

An updated view into the cell cycle kinetics of human T lymphocytes and the impact of irradiation

E Duthoo, A Vral, A Baeyens - Scientific Reports, 2022 - nature.com
Even though a detailed understanding of the proliferative characteristics of T lymphocytes is
imperative in many research fields, prior studies have never reached a consensus on these …