Neuropeptides play important modulatory roles throughout the nervous system, functioning
as direct effectors or as interacting partners with other neuropeptide and neurotransmitter …

Capsaicin, the pungent ingredient in chili peppers, produces intense burning pain in
humans. Capsaicin selectively activates the transient receptor potential vanilloid 1 (TRPV1) …

For decades, basic research on the underlying mechanisms of nociception has held promise
to translate into efficacious treatments for patients with pain. Despite great improvement in …

Descending pain inhibition is a key component of physiological and pathological pain
processing. 70 Various neurotransmitter systems underlie different descending pain …

Neuroplasticity in cortico-limbic circuits has been implicated in pain persistence and pain
modulation in clinical and preclinical studies. The amygdala has emerged as a key player in …

The amygdala is a key subcortical region believed to contribute to emotional components of
pain. As opioid receptors are found in both the central (CeA) and basolateral (BLA) nuclei of …

Objective: A pre/post pilot study was designed to investigate neurobiological mechanisms
and plasma metabolites in an 8-week Tai-Chi (TC) group intervention in subjects with knee …

Background The efficiency of descending pain modulation, commonly assessed with the
conditioned pain modulation procedure, is diminished in patients with chronic pain. The …

Functional pain syndromes (FPS) occur in the absence of identifiable tissue injury or
noxious events and include conditions such as migraine, fibromyalgia, and others. Stressors …

The amygdala has emerged as a key player in the emotional response to pain and pain
modulation. The lateral and capsular regions of the central nucleus of the amygdala (CeA) …