Direct oral anticoagulants (DOACs) are small molecule inhibitors of the coagulation
proteases thrombin and factor Xa that demonstrate comparable efficacy to warfarin for …

For decades, it was considered that plasma kallikrein's (PKa) sole function within the
coagulation cascade is the activation of factor (F) XII. Until recently, the two key known …

Background: High blood cholesterol accelerates the progression of atherosclerosis, which is
an asymptomatic process lasting for decades. Rupture of atherosclerotic plaques induces …

Background: In view of the large heterogeneity in the clinical presentation of hereditary
angioedema due to C1 inhibitor deficiency (C1-INH-HAE), great efforts are being made …

Plasma prekallikrein (PK) has a critical role in acute attacks of hereditary angioedema
(HAE). Unlike C1 inhibitor, its levels fall during HAE attacks with resultant cleaved high …

Objective Bevacizumab, a monoclonal antibody to VEGF, has shown efficacy in ovarian,
cervical and endometrial cancer in addition to several other solid tumors. Serious side …

These investigations indicate that the proteins of the contact activation and kallikrein/kinin
systems influence thrombosis risk by several mechanisms and understanding of these …

Prolylcarboxypeptidase (PRCP, PCP, Lysosomal Pro-X-carboxypeptidase, Angiotensinase
C) controls angiotensin-and kinin-induced cell signaling. Elevation of PRCP appears to be …

We determined the relationship between plasma kallikrein and cardiovascular disease
(CVD) outcomes as well as major adverse cardiovascular events (MACE) in the Diabetes …

Background Recent evidence has revealed that circulating coagulation factor prekallikrein
(PK), an important part of the kallikrein-kinin system, regulates cholesterol metabolism, but …