Aging of the brain can manifest itself as a memory and cognitive decline, which has been
shown to frequently coincide with changes in the structural plasticity of dendritic spines …

Normal ageing is associated with impairments in cognitive function, including memory.
These impairments are linked, not to a loss of neurons in the forebrain, but to specific and …

The mechanisms involved in plasticity in the nervous system are thought to support
cognition, and some of these processes are affected during normal ageing. Notably …

Brain plasticity refers to the remarkable property of cerebral neurons to change their
structure and function in response to experience, a fundamental theoretical theme in the …

Age-associated memory impairment (AAMI) occurs in many mammalian species, including
humans. In contrast to Alzheimer's disease (AD), in which circuit disruption occurs through …

Given the rapid rate of population aging and the increased incidence of cognitive decline
and neurodegenerative diseases with advanced age, it is important to ascertain the …

Structural changes of neurons in the brain during aging are complex and not well
understood. Neurons have significant homeostatic control of essential brain functions …

The brain's ability to process complex information relies on the constant supply of energy
through aerobic respiration by mitochondria. Neurons contain three anatomically distinct …

Brain networks that engage the hippocampus and prefrontal cortex are central for enabling
effective interactions with our environment. Some of the cognitive processes that these …

An electron microscopic analysis has been carried out on the effects of age on the numerical
density of both excitatory (asymmetric) and inhibitory (symmetric) synapses in the neuropil of …