Vaccine adjuvants interact with the immune system, to increase the potency of vaccine
antigens. Many of the adjuvants currently available were developed with little understanding …

Abstract Formulation science is an unappreciated and often overlooked aspect in the field of
vaccinology. In this review we highlight key attributes necessary to generate well …

Despite the progress of conventional vaccines, improvements are clearly required due to
concerns about the weak immunogenicity of these vaccines, intrinsic instability in vivo …

Background GMZ2 is a recombinant protein malaria vaccine, comprising two blood-stage
antigens of Plasmodium falciparum, glutamate-rich protein and merozoite surface protein 3 …

Macromolecular biomolecules are currently dethroning classical small molecule
therapeutics because of their improved targeting and delivery properties. Protamine-a small …

Abstract Design Safety and immunogenicity of a recombinant 14 kDa, fatty acid-binding
protein (FABP) from Schistosoma mansoni (rSm14) were evaluated through an open, non …

The Plasmodium falciparum Pf s230 and Pf s48/45 proteins are expressed during
transmission from man to mosquito and are leading candidates for a malaria transmission …

Background. GMZ2 is a hybrid protein consisting of the N-terminal region of the glutamate-
rich protein fused in frame to the C-terminal region of merozoite surface protein 3 (MSP3) …

The synthetic TLR4 agonist glucopyranosyl lipid adjuvant (GLA) is a potent Th1‐response‐
inducing adjuvant when formulated in a squalene oil‐in‐water emulsion (SE). While the …

Abstract The Plasmodium falciparum Pfs230 and Pfs48/45 proteins are leading candidates
for a malaria transmission-blocking vaccine (TBV). Previously, we showed that a Pfs230 …