Radiation-induced bystander phenomenon: insight and implications in radiotherapy

S Mukherjee, A Chakraborty - International journal of radiation …, 2019 - Taylor & Francis
Despite the extensive utilization of radiotherapy in cancer treatments, clinicians often face
challenges in achieving desired outcomes. This is because of the existence of secondary …

Melanoma: Last call for radiotherapy

S Espenel, A Vallard, C Rancoule, MA Garcia… - Critical reviews in …, 2017 - Elsevier
Melanoma is traditionally considered to be a radioresistant tumor. However, radiotherapy
and immunotherapy latest developments might upset this radiobiological dogma …

[HTML][HTML] Exosomes derived from mesenchymal stem cells enhance radiotherapy-induced cell death in tumor and metastatic tumor foci

V de Araujo Farias, F O'Valle, S Serrano-Saenz… - Molecular Cancer, 2018 - Springer
Background We have recently shown that radiotherapy may not only be a successful local
and regional treatment but, when combined with MSCs, may also be a novel systemic …

[HTML][HTML] The TLR7 agonist imiquimod induces anti-cancer effects via autophagic cell death and enhances anti-tumoral and systemic immunity during radiotherapy for …

JH Cho, HJ Lee, HJ Ko, BI Yoon, J Choe, KC Kim… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Toll-like receptor (TLR) ligands are strongly considered immune-adjuvants for cancer
immunotherapy and have been shown to exert direct anti-cancer effects. This study was …

Improved anticancer photothermal therapy using the bystander effect enhanced by antiarrhythmic peptide conjugated dopamine‐modified reduced graphene oxide …

J Yu, YH Lin, L Yang, CC Huang… - Advanced …, 2017 - Wiley Online Library
Despite tremendous efforts toward developing novel near‐infrared (NIR)‐absorbing
nanomaterials, improvement in therapeutic efficiency remains a formidable challenge in …

Bystander effects and their implications for clinical radiation therapy: Insights from multiscale in silico experiments

GG Powathil, AJ Munro, MAJ Chaplain… - Journal of theoretical …, 2016 - Elsevier
Radiotherapy is a commonly used treatment for cancer and is usually given in varying
doses. At low radiation doses relatively few cells die as a direct response to radiation but …

[HTML][HTML] Enhancing the bystander and abscopal effects to improve radiotherapy outcomes

VA Farias, I Tovar, R Del Moral, F O'Valle… - Frontiers in …, 2020 - frontiersin.org
In this paper, we summarize published articles and experiences related to the attempt to
improve radiotherapy outcomes and, thus, to personalize the radiation treatment according …

[HTML][HTML] Radiation Induced Bystander Effect: From in Vitro Studies to Clinical Application

M Widel - International Journal of Medical Physics, Clinical …, 2016 - scirp.org
In the past 20 years, the classic paradigm in radiobiology recognizing DNA as the main
target for the action of radiation has changed. The new paradigm assumes that both targeted …

[HTML][HTML] Radiation-induced bystander effect and cytoplasmic irradiation studies with microbeams

Z Zhang, K Li, M Hong - Biology, 2022 - mdpi.com
Simple Summary Microbeams are useful tools in studies on non-target effects, such as the
radiation-induced bystander effect, and responses related to cytoplasmic irradiation. A …

Mechanisms of Melanoma Progression and Treatment Resistance: Role of Cancer Stem-like Cells

Y Al Hmada, RT Brodell, N Kharouf, TW Flanagan… - Cancers, 2024 - mdpi.com
Simple Summary Melanoma is the third most common type of skin cancer. Melanoma is a
heterogeneous tumor, composed of genetically divergent subpopulations. These …