Every year more than 13 million deaths worldwide are due to environmental pollutants, and
approximately 24% of diseases are caused by environmental exposures that might be …

Background Biomarkers that can predict the prognosis of colorectal cancer (CRC) patients
and that can stratify high-risk early stage patients from low-risk early stage patients are …

Background Silencing of tumor suppressor genes plays a vital role in head and neck
carcinogenesis. In this study we aimed to evaluate aberrant p16INK4a gene promoter …

Purpose: Several studies have examined the potential role of p16 protein expression as a
diagnostic and prognostic biomarker in various cancers. However, it remains unclear …

The inactivation of the cyclin-dependent kinase inhibitor p16INK4A gene by
hypermethylation is observed in numerous types of cancer. New findings indicate that DNA …

Though benign, giant cell tumor of bone (GCTB) can become aggressive and can exhibit a
high mitotic rate, necrosis and rarely vascular invasion and metastasis. GCTB has unique …

SUMMARY DNA methylation patterns may be used as innovative biomarkers for some
pathologies including cancer. They show a great accessibility due to their stability and …

Background Colorectal carcinoma (CRC) is a major cause of morbidity and mortality
worldwide. It is a multistep process that arises because of the cumulative effect of mutations …

Every year more than 13 million deaths worldwide are due to environmental pollutants, and
approximately 24% of diseases are caused by environmental exposures that might be …

Several malignant tumors are associated with decreased expression of tumor suppressor
gene P16 and one of the common causes of this suppression is epigenetic modification as …