Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions

C Qin, S Yang, YH Chu, H Zhang, XW Pang… - Signal transduction and …, 2022 - nature.com
Ischemic stroke is caused primarily by an interruption in cerebral blood flow, which induces
severe neural injuries, and is one of the leading causes of death and disability worldwide …

Pathophysiology of ischemic stroke: role of oxidative stress

S Orellana-Urzúa, I Rojas, L Líbano… - Current …, 2020 - ingentaconnect.com
Stroke is the second leading cause of mortality and the major cause of adult physical
disability worldwide. The currently available treatment to recanalize the blood flow in acute …

Cerium oxide nanoparticles with antioxidative neurorestoration for ischemic stroke

X Li, Z Han, T Wang, C Ma, H Li, H Lei, Y Yang… - Biomaterials, 2022 - Elsevier
Oxidative stress and mitochondrial damage are the main mechanisms of ischemia-
reperfusion injury in ischemic stroke. Herein, cerium oxide nanoparticles with powerful free …

Nanozymes for regenerative medicine

X Mou, Q Wu, Z Zhang, Y Liu, J Zhang, C Zhang… - Small …, 2022 - Wiley Online Library
Nanozymes refer to nanomaterials that catalyze enzyme substrates into products under
relevant physiological conditions following enzyme kinetics. Compared to natural enzymes …

Crosstalk between the oxidative stress and glia cells after stroke: from mechanism to therapies

G Zhu, X Wang, L Chen, C Lenahan, Z Fu… - Frontiers in …, 2022 - frontiersin.org
Stroke is the second leading cause of global death and is characterized by high rates of
mortality and disability. Oxidative stress is accompanied by other pathological processes …

Mitochondrial dysfunctions induce PANoptosis and ferroptosis in cerebral ischemia/reperfusion injury: from pathology to therapeutic potential

R She, D Liu, J Liao, G Wang, J Ge… - Frontiers in Cellular …, 2023 - frontiersin.org
Ischemic stroke (IS) accounts for more than 80% of the total stroke, which represents the
leading cause of mortality and disability worldwide. Cerebral ischemia/reperfusion injury …

Stroke: Molecular mechanisms and therapies: Update on recent developments

F Shehjar, B Maktabi, ZA Rahman, GA Bahader… - Neurochemistry …, 2023 - Elsevier
Stroke, a neurological disease, is one of the leading causes of death worldwide, resulting in
long-term disability in most survivors. Annual stroke costs in the United States alone were …

[HTML][HTML] Dodging blood brain barrier with “nano” warriors: Novel strategy against ischemic stroke

S Parvez, M Kaushik, M Ali, MM Alam, J Ali… - Theranostics, 2022 - ncbi.nlm.nih.gov
Ischemic stroke (IS) is one of the leading causes of death and disability resulting in
inevitable burden globally. Ischemic injury initiates cascade of pathological events …

Disorders of endogenous and exogenous antioxidants in neurological diseases

I Korczowska-Łącka, B Słowikowski, T Piekut, M Hurła… - Antioxidants, 2023 - mdpi.com
In diseases of the central nervous system, such as Alzheimer's disease (AD), Parkinson's
disease (PD), stroke, amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), and …

Effects of mdivi-1 on neural mitochondrial dysfunction and mitochondria-mediated apoptosis in ischemia-reperfusion injury after stroke: A systematic review of …

NT Nhu, Q Li, Y Liu, J Xu, SY Xiao… - Frontiers in molecular …, 2021 - frontiersin.org
This systematic review sought to determine the effects of Mitochondrial division inhibitor-1
(Mdivi-1) on neural mitochondrial dysfunction and neural mitochondria-mediated apoptosis …