Regulation of the nucleic acid-sensing Toll-like receptors

NA Lind, VE Rael, K Pestal, B Liu… - Nature Reviews …, 2022 - nature.com
Many of the ligands for Toll-like receptors (TLRs) are unique to microorganisms, such that
receptor activation unequivocally indicates the presence of something foreign. However, a …

The immune nature of platelets revisited

A Maouia, J Rebetz, R Kapur, JW Semple - Transfusion medicine reviews, 2020 - Elsevier
Platelets are the primary cellular mediators of hemostasis and this function firmly acquaints
them with a variety of inflammatory processes. For example, platelets can act as circulating …

Toll-like receptor-guided therapeutic intervention of human cancers: molecular and immunological perspectives

S Mukherjee, R Patra, P Behzadi, A Masotti… - Frontiers in …, 2023 - frontiersin.org
Toll-like receptors (TLRs) serve as the body's first line of defense, recognizing both
pathogen-expressed molecules and host-derived molecules released from damaged or …

Covid-19 automated diagnosis and risk assessment through metabolomics and machine learning

J Delafiori, LC Navarro, RF Siciliano… - Analytical …, 2021 - ACS Publications
COVID-19 is still placing a heavy health and financial burden worldwide. Impairment in
patient screening and risk management plays a fundamental role on how governments and …

Toll-like receptor (TLRs) agonists and antagonists for COVID-19 treatments

ZM Liu, MH Yang, K Yu, ZX Lian… - Frontiers in Pharmacology, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) rapidly infects
humans and animals which make coronavirus disease 2019 (COVID-19) a grievous …

Metabolomic profiling of plasma reveals differential disease severity markers in COVID-19 patients

LB Oliveira, VI Mwangi, MA Sartim, J Delafiori… - Frontiers in …, 2022 - frontiersin.org
The severity, disabilities, and lethality caused by the coronavirus 2019 (COVID-19) disease
have dumbfounded the entire world on an unprecedented scale. The multifactorial aspect of …

[HTML][HTML] Effects of autochthonous starter cultures on bacterial communities and metabolites during fermentation of Yu jiangsuan, a Chinese traditional fermented …

L Jiang, L Liu, H Chen, W Zhang, L He, X Zeng - LWT, 2022 - Elsevier
The study on the bacterial community structure and metabolite effects of fermentation of Yu
jiangsuan (YJS) by autochthonous starter cultures has been rarely reported. In this study, the …

Activation of toll-like receptor 7 signaling pathway in primary Sjögren's syndrome-associated thrombocytopenia

S Zhang, J Qu, L Wang, M Li, D Xu, Y Zhao… - Frontiers in …, 2021 - frontiersin.org
Objectives: To identify the importance of the Toll-like receptor (TLR) pathway using B cell
high-throughput sequencing and to explore the participation of the TLR7 signaling pathway …

Design and Characterization of Compact, Programmable, Multistranded Nonimmunostimulatory Nucleic Acid Nanoparticles Suitable for Biomedical Applications

R Brumett, L Danai, A Coffman, Y Radwan, M Teter… - Biochemistry, 2024 - ACS Publications
We report a thorough investigation of the role of single-stranded thymidine (ssT) linkers in
the stability and flexibility of minimal, multistranded DNA nanostructures. We systematically …

The role of toll-like receptors (TLRs) in pan-cancer

R Huang, Z Sun, S Xian, D Song, Z Chang… - Annals of …, 2022 - Taylor & Francis
Abstract Background Toll-like receptors (TLRs) are important components of the innate and
adaptive immune systems, and abnormal TLR expression has been linked to a variety of …