Over the last 100–120 years, due to the ever-increasing importance of fluorine-containing
compounds in modern technology and daily life, the explosive development of the …

This Perspective surveys the progress and current limitations of nucleophilic fluorination
methodologies. Despite the long and rich history of C (sp3)–F bond construction in chemical …

Background Systemic therapies are typically combined with topical corticosteroids for the
management of moderate-to-severe atopic dermatitis. Upadacitinib is an oral Janus kinase …

The electronic properties and relatively small size of fluorine endow it with considerable
versatility as a bioisostere and it has found application as a substitute for lone pairs of …

The concept of functional groups (FGs), sets of connected atoms that can determine the
intrinsic reactivity of the parent molecule and in part are responsible for the overall …

The role of fluorine in drug design and development is expanding rapidly as we learn more
about the unique properties associated with this unusual element and how to deploy it with …

This review describes the recent Food and Drug Administration (FDA)-approved drugs (in
the year 2021) containing at least one halogen atom (covalently bound). The structures …

Fluorine has emerged as a “magic element” in medicinal chemistry, crop, and materials
science. 1 Although fluorine is the most abundant halogen in the earth's crust, it is contained …

Broad antibacterial spectrum, high oral bioavailability and excellent tissue penetration
combined with safety and few, yet rare, unwanted effects, have made the quinolones class of …

Fluorine compounds are known for their abundance in more than 20% of pharmaceutical
and agrochemical products mainly due to the enhanced lipophilicity, metabolic stability and …