[HTML][HTML] Potent bioactive compounds from seaweed waste to combat cancer through bioinformatics investigation

KK Bharadwaj, I Ahmad, S Pati, A Ghosh… - Frontiers in …, 2022 - frontiersin.org
The seaweed industries generate considerable amounts of waste that must be appropriately
managed. This biomass from marine waste is a rich source of high-value bioactive …

Design, synthesis, in vitro anticancer and antimicrobial evaluation, SAR analysis, molecular docking and dynamic simulation of new pyrazoles, triazoles and …

HA Radwan, I Ahmad, IMM Othman… - Journal of Molecular …, 2022 - Elsevier
A new series of pyrazoles, triazoles and pyridazines based isoxazole were synthesized, and
well characterized. Their antibacterial, antifungal and cytotoxic activities were successfully …

Spectroscopic characterization, polar solvation effects, DFT studies, and the antiviral inhibitory potency of a novel terpolymer based on p-Phenylenediamine …

N Mujafarkani, MA Ojong, AJ Ahamed… - Journal of Molecular …, 2023 - Elsevier
This study articulates the synthesis, spectroscopic characterization, solvation effects,
theoretical calculations, and molecular docking analysis of a novel p-Phenylenediamine …

[HTML][HTML] Introduction of benzyloxy pharmacophore into aryl/heteroaryl chalcone motifs as a new class of monoamine oxidase B inhibitors

ST Sudevan, JM Oh, MA Abdelgawad… - Scientific reports, 2022 - nature.com
The inhibitory action of fifteen benzyloxy ortho/para-substituted chalcones (B1-B15) was
evaluated against human monoamine oxidases (hMAOs). All the molecules inhibited hMAO …

In-vitro anticancer evaluation of newly designed and characterized tri/tetra-substituted imidazole congeners-maternal embryonic leucine zipper kinase inhibitors …

M Mahapatra, P Mohapatra, K Pakeeraiah… - International Journal of …, 2023 - Elsevier
Our cascading attempt to develop new potent molecules now involves designing a series of
imidazole derivatives and synthesizing two sets of 2, 4, 5-tri-substituted (4a–4d) and 1, 2, 4 …

[HTML][HTML] Progress on COVID-19 chemotherapeutics discovery and novel technology

Y Zhou, H Wang, L Yang, Q Wang - Molecules, 2022 - mdpi.com
COVID-19 is an infectious disease caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), a novel highly contagious and pathogenic coronavirus that …

Synthesizes, characterization, molecular docking and in vitro bioactivity study of new compounds containing triple beta lactam rings

MM Farhan, MA Guma, MA Rabeea, I Ahmad… - Journal of Molecular …, 2022 - Elsevier
Penicillin bioactivity is continuously decreased due to the misuses by people which resulted
in an antibiotics resistance. However, B-lactam ring is still an effect group the attack bacterial …

[HTML][HTML] Design, synthesis, biological evaluation and in silico studies of novel 1, 2, 3-triazole linked benzoxazine-2, 4-dione conjugates as potent antimicrobial …

MB Hammouda, I Ahmad, A Hamdi, A Dbeibia… - Arabian Journal of …, 2022 - Elsevier
In an attempt to rationalize the search for new potential anti-inflammatory and anti-infection
agents, a new series of 1, 4-and 1, 5-disubstituted 1, 2, 3-triazoles linked benzoxazine …

Evaluation of oxindole derivatives as a potential anticancer agent against breast carcinoma cells: In vitro, in silico, and molecular docking study

S Puri, I Ahmad, H Patel, K Kumar, K Juvale - Toxicology in Vitro, 2023 - Elsevier
In this study we have performed the in vitro anticancer activity of spiro oxindole derivatives
against MCF-7 (human Adreno carcinoma) and MDA-MB-231 (triple negative breast cancer) …

[HTML][HTML] In silico investigations identified Butyl Xanalterate to competently target CK2α (CSNK2A1) for therapy of chronic lymphocytic leukemia

SA Alsagaby, D Iqbal, I Ahmad, H Patel, SA Mir… - Scientific reports, 2022 - nature.com
Chronic lymphocytic leukemia (CLL) is an incurable malignancy of B-cells. In this study,
bioinformatics analyses were conducted to identify possible pathogenic roles of CK2α …