[HTML][HTML] Potent bioactive compounds from seaweed waste to combat cancer through bioinformatics investigation
The seaweed industries generate considerable amounts of waste that must be appropriately
managed. This biomass from marine waste is a rich source of high-value bioactive …
managed. This biomass from marine waste is a rich source of high-value bioactive …
Design, synthesis, in vitro anticancer and antimicrobial evaluation, SAR analysis, molecular docking and dynamic simulation of new pyrazoles, triazoles and …
HA Radwan, I Ahmad, IMM Othman… - Journal of Molecular …, 2022 - Elsevier
A new series of pyrazoles, triazoles and pyridazines based isoxazole were synthesized, and
well characterized. Their antibacterial, antifungal and cytotoxic activities were successfully …
well characterized. Their antibacterial, antifungal and cytotoxic activities were successfully …
Spectroscopic characterization, polar solvation effects, DFT studies, and the antiviral inhibitory potency of a novel terpolymer based on p-Phenylenediamine …
N Mujafarkani, MA Ojong, AJ Ahamed… - Journal of Molecular …, 2023 - Elsevier
This study articulates the synthesis, spectroscopic characterization, solvation effects,
theoretical calculations, and molecular docking analysis of a novel p-Phenylenediamine …
theoretical calculations, and molecular docking analysis of a novel p-Phenylenediamine …
[HTML][HTML] Introduction of benzyloxy pharmacophore into aryl/heteroaryl chalcone motifs as a new class of monoamine oxidase B inhibitors
ST Sudevan, JM Oh, MA Abdelgawad… - Scientific reports, 2022 - nature.com
The inhibitory action of fifteen benzyloxy ortho/para-substituted chalcones (B1-B15) was
evaluated against human monoamine oxidases (hMAOs). All the molecules inhibited hMAO …
evaluated against human monoamine oxidases (hMAOs). All the molecules inhibited hMAO …
In-vitro anticancer evaluation of newly designed and characterized tri/tetra-substituted imidazole congeners-maternal embryonic leucine zipper kinase inhibitors …
M Mahapatra, P Mohapatra, K Pakeeraiah… - International Journal of …, 2023 - Elsevier
Our cascading attempt to develop new potent molecules now involves designing a series of
imidazole derivatives and synthesizing two sets of 2, 4, 5-tri-substituted (4a–4d) and 1, 2, 4 …
imidazole derivatives and synthesizing two sets of 2, 4, 5-tri-substituted (4a–4d) and 1, 2, 4 …
[HTML][HTML] Progress on COVID-19 chemotherapeutics discovery and novel technology
Y Zhou, H Wang, L Yang, Q Wang - Molecules, 2022 - mdpi.com
COVID-19 is an infectious disease caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), a novel highly contagious and pathogenic coronavirus that …
coronavirus 2 (SARS-CoV-2), a novel highly contagious and pathogenic coronavirus that …
Synthesizes, characterization, molecular docking and in vitro bioactivity study of new compounds containing triple beta lactam rings
Penicillin bioactivity is continuously decreased due to the misuses by people which resulted
in an antibiotics resistance. However, B-lactam ring is still an effect group the attack bacterial …
in an antibiotics resistance. However, B-lactam ring is still an effect group the attack bacterial …
[HTML][HTML] Design, synthesis, biological evaluation and in silico studies of novel 1, 2, 3-triazole linked benzoxazine-2, 4-dione conjugates as potent antimicrobial …
MB Hammouda, I Ahmad, A Hamdi, A Dbeibia… - Arabian Journal of …, 2022 - Elsevier
In an attempt to rationalize the search for new potential anti-inflammatory and anti-infection
agents, a new series of 1, 4-and 1, 5-disubstituted 1, 2, 3-triazoles linked benzoxazine …
agents, a new series of 1, 4-and 1, 5-disubstituted 1, 2, 3-triazoles linked benzoxazine …
Evaluation of oxindole derivatives as a potential anticancer agent against breast carcinoma cells: In vitro, in silico, and molecular docking study
In this study we have performed the in vitro anticancer activity of spiro oxindole derivatives
against MCF-7 (human Adreno carcinoma) and MDA-MB-231 (triple negative breast cancer) …
against MCF-7 (human Adreno carcinoma) and MDA-MB-231 (triple negative breast cancer) …
[HTML][HTML] In silico investigations identified Butyl Xanalterate to competently target CK2α (CSNK2A1) for therapy of chronic lymphocytic leukemia
Chronic lymphocytic leukemia (CLL) is an incurable malignancy of B-cells. In this study,
bioinformatics analyses were conducted to identify possible pathogenic roles of CK2α …
bioinformatics analyses were conducted to identify possible pathogenic roles of CK2α …