Regulation of membrane protein structure and function by their lipid nano-environment

I Levental, E Lyman - Nature Reviews Molecular Cell Biology, 2023 - nature.com
Transmembrane proteins comprise~ 30% of the mammalian proteome, mediating
metabolism, signalling, transport and many other functions required for cellular life. The …

Membrane homeostasis beyond fluidity: control of membrane compressibility

MF Renne, R Ernst - Trends in Biochemical Sciences, 2023 - cell.com
Biomembranes are complex materials composed of lipids and proteins that
compartmentalize biochemistry. They are actively remodeled in response to physical and …

Lipid saturation controls nuclear envelope function

A Romanauska, A Köhler - Nature Cell Biology, 2023 - nature.com
The nuclear envelope (NE) is a spherical double membrane with elastic properties. How NE
shape and elasticity are regulated by lipid chemistry is unknown. Here we discover lipid acyl …

Systematic design of cell membrane coating to improve tumor targeting of nanoparticles

L Liu, D Pan, S Chen, MV Martikainen… - Nature …, 2022 - nature.com
Cell membrane (CM) coating technology is increasingly being applied in nanomedicine, but
the entire coating procedure including adsorption, rupture, and fusion is not completely …

Hot topic: Thermosensing in plants

S Hayes, J Schachtschabel, M Mishkind… - Plant, Cell & …, 2021 - Wiley Online Library
Plants alter their morphology and cellular homeostasis to promote resilience under a variety
of heat regimes. Molecular processes that underlie these responses have been intensively …

Low membrane fluidity triggers lipid phase separation and protein segregation in living bacteria

M Gohrbandt, A Lipski, JW Grimshaw… - The EMBO …, 2022 - embopress.org
All living organisms adapt their membrane lipid composition in response to changes in their
environment or diet. These conserved membrane‐adaptive processes have been studied …

Cristae formation is a mechanical buckling event controlled by the inner mitochondrial membrane lipidome

K Venkatraman, CT Lee, GC Garcia… - The EMBO …, 2023 - embopress.org
Cristae are high‐curvature structures in the inner mitochondrial membrane (IMM) that are
crucial for ATP production. While cristae‐shaping proteins have been defined, analogous …

Regulation of immune receptor kinase plasma membrane nanoscale organization by a plant peptide hormone and its receptors

J Gronnier, CM Franck, M Stegmann, TA DeFalco… - Elife, 2022 - elifesciences.org
Spatial partitioning is a propensity of biological systems orchestrating cell activities in space
and time. The dynamic regulation of plasma membrane nano-environments has recently …

Roles of polyunsaturated fatty acids, from mediators to membranes

T Harayama, T Shimizu - Journal of lipid research, 2020 - ASBMB
PUFAs, such as AA and DHA, are recognized as important biomolecules, but understanding
their precise roles and modes of action remains challenging. PUFAs are precursors for a …

The ubiquitous role of ubiquitination in lipid metabolism

M Loix, N Zelcer, JFJ Bogie, JJA Hendriks - Trends in Cell Biology, 2024 - cell.com
Lipids are essential molecules that play key roles in cell physiology by serving as structural
components, for storage of energy, and in signal transduction. Hence, efficient regulation …