Oxidative stress (OS), caused by the imbalance between the generation and detoxification of
reactive oxygen and nitrogen species (ROS/RNS), plays an important role in brain aging …

Alzheimer's disease (AD) is a chronic neurodegenerative disorder, characterized by
synaptic degeneration associated with fibrillar aggregates of the amyloid-ß peptide and the …

Reactivation of the cell cycle, including DNA replication, might play a major role in
Alzheimer's disease (AD). A more than diploid DNA content in differentiated neurons might …

Ochratoxin-A (OTA) is a fungal metabolite with potential toxic effects on the central nervous
system that have not yet been fully characterized. OTA has complex mechanisms of action …

To determine whether oxidative stress after cerebral ischemia–reperfusion affects genetic
stability in the brain, we studied mutagenesis after forebrain ischemia–reperfusion in Big …

2.2. 1. Association of free radical formation with neurodegenerative diseases 2.2. 2. Metal-
catalysed free radical formation 2.3. Glutamate and glutamate agonists 2.3. 1. Animal …

The toxicity of the cyanobacterial modified amino acid, BMAA, has been described in rat,
mouse and leech neurons. Particular emphasis has been placed on the potential ability of …

DNA repair is essential for maintaining the integrity of the nucleotide sequence of cellular
DNA over time. Although much information has accumulated recently on the mechanisms of …

Article abstract-We investigated the asymmetry of focal deficits of bradykinesia in a cross-
sectional study of 198 patients with idiopathic parkinsonism. We have analyzed the …

Introduction 3. Materials and methods 3.1. Animal model 3.2. Measurement of infarct volume
3.3. Measurement of 8-OhdG content using HPLC-EC detection 3.4. Quantitative …