WNT/β-catenin signaling is involved in many physiological processes. Its implication in
embryonic development, cell migration, and polarization has been shown. Nevertheless …

There has been a surge of interest in recent years in understanding the intricate
mechanisms underlying cancer progression and treatment resistance. One molecule that …

Leukemia is a clonal malignant hematopoietic stem cell disease. It is the sixth most lethal
cancer and accounts for 4% of all cancers. The main form of treatment for leukemia is …

Cancer outcome has improved since introduction of target therapy. However, treatment
success is still impaired by the same drug resistance mechanism of classical chemotherapy …

Having found previously that leukemic cells with multidrug resistant (MDR) phenotype, but
not their sensitive counterparts, exhibit collateral sensitivity to cold stress in a P-gp …

Collateral sensitivity is a term for the hypersensitivity of otherwise drug-resistant cells. The
selective killing of tumor cells by drugs exerting collateral sensitivity might be used as a …

The acquisition of a multidrug-resistant (MDR) phenotype by tumor cells is one of the main
causes of chemotherapy failure in cancer, and, usually, is due to the increased expression of …

Multi-drug resistance (MDR) is a common phenomenon produced in cancer by the loss of
therapeutic response in spite of the wide spectrum of drugs prescribed. Hematologic …

The unifying element tying together the therapeutics presented in this thesis is annexin A5.
The protein, annexin 5 (ANXA5), is a membrane management protein that specifically binds …