The hyper-IgE syndromes (HIES) are a heterogeneous group of inborn errors of immunity
sharing manifestations including increased infection susceptibility, eczema, and raised …

Primary immunodeficiencies (PIDs) provide researchers with unique models to understand
in vivo immune responses in general and immunity to infections in particular. In humans …

Abstract Dedicator of cytokinesis 8 (DOCK8) deficiency is a combined immunodeficiency
that exemplifies the broad clinical features of primary immunodeficiencies (PIDs), extending …

Hyper IgE syndromes comprise a group of rare primary immunodeficiency disorders
characterized by a triad of atopic dermatitis, recurrent skin and lung infections along with …

Background Increasing evidence links genetic defects affecting actin-regulatory proteins to
diseases with severe autoimmunity and autoinflammation, yet the underlying molecular …

Infections with any of the nine human herpes viruses (HHV) can be asymptomatic or life-
threatening. The study of patients with severe diseases caused by HHVs, in the absence of …

Malignancies occur with a higher incidence rate and manifest earlier in life in patients with
primary immunodeficiency disorders (PIDs) than in the general population. However, no …

The total number of acquired melanocytic nevi on the skin is strongly correlated with
melanoma risk. Here we report a meta-analysis of 11 nevus GWAS from Australia …

Combined immunodeficiency (CID) refers to inborn errors of human T cells that also affect B
cells because of the T cell deficit or an additional B cell–intrinsic deficit. In this study, we …

Epstein–Barr Virus (EBV) is a gamma-herpes virus that infects 90% of humans without any
symptoms in most cases, but has an oncogenic potential, especially in immunocompromised …