Traumatic spinal cord injury (SCI) is a life changing neurological condition with substantial
socioeconomic implications for patients and their care-givers. Recent advances in medical …

Traumatic spinal cord injury results in severe and irreversible loss of function. The injury
triggers a complex cascade of inflammatory and pathological processes, culminating in …

The extracellular matrix (ECM) proteoglycan, versican increases along with other ECM
versican binding molecules such as hyaluronan, tumor necrosis factor stimulated gene-6 …

Severe spinal cord injury causes permanent loss of function and sensation throughout the
body. The trauma causes a multifaceted torrent of pathophysiological processes which …

Chondroitin sulfate proteoglycans (CSPGs) act as potent inhibitors of axonal growth and
neuroplasticity after spinal cord injury (SCI). Here we reveal that CSPGs also play a critical …

It is uncontested that perivascular spaces play critical roles in maintaining homeostasis and
priming neuroinflammation. However, despite more than a century of intense research on …

Remyelination failure contributes to axonal loss and progression of disability in multiple
sclerosis. The failed repair process could be due to ongoing toxic neuroinflammation and to …

The rapidly evolving therapeutic landscape of multiple sclerosis (MS) has contributed to
paradigm shifts in our understanding of the biological mechanisms that contribute to CNS …

Immune cells mediate critical inflammatory and neurodegenerative processes in the CNS in
individuals with multiple sclerosis (MS). In MS, activated microglia, border-associated …

Microglia and infiltrating macrophages are thought to orchestrate the central nervous system
(CNS) response to injury; however, the similarities between these cells make it challenging …