Narcolepsy—clinical spectrum, aetiopathophysiology, diagnosis and treatment

CLA Bassetti, A Adamantidis, D Burdakov… - Nature Reviews …, 2019 - nature.com
Narcolepsy is a rare brain disorder that reflects a selective loss or dysfunction of orexin (also
known as hypocretin) neurons of the lateral hypothalamus. Narcolepsy type 1 (NT1) is …

European guideline and expert statements on the management of narcolepsy in adults and children

CLA Bassetti, U Kallweit, L Vignatelli… - European journal of …, 2021 - Wiley Online Library
Background and aim Narcolepsy is an uncommon hypothalamic disorder of presumed
autoimmune origin that usually requires lifelong treatment. This paper aims to provide …

Narcolepsy

BR Kornum, S Knudsen, HM Ollila, F Pizza… - Nature reviews Disease …, 2017 - nature.com
Narcolepsy is a chronic sleep disorder that has a typical onset in adolescence and is
characterized by excessive daytime sleepiness, which can have severe consequences for …

The social and economic cost of sleep disorders

J Streatfeild, J Smith, D Mansfield, L Pezzullo… - Sleep, 2021 - academic.oup.com
Abstract Study Objectives To estimate economic cost of common sleep disorders in Australia
for 2019–2020. Methods Costs were estimated for obstructive sleep apnea (OSA), insomnia …

Co-morbidity, mortality, quality of life and the healthcare/welfare/social costs of disordered sleep: a rapid review

S Garbarino, P Lanteri, P Durando… - International journal of …, 2016 - mdpi.com
Sleep disorders are frequent (18%–23%) and constitute a major risk factor for psychiatric,
cardiovascular, metabolic or hormonal co-morbidity and mortality. Low social status or …

Narcolepsy as an autoimmune disease: the role of H1N1 infection and vaccination

M Partinen, BR Kornum, G Plazzi, P Jennum… - The Lancet …, 2014 - thelancet.com
Narcolepsy is a sleep disorder characterised by loss of hypothalamic hypocretin (orexin)
neurons. The prevalence of narcolepsy is about 30 per 100 000 people, and typical age at …

Delayed diagnosis of narcolepsy: characterization and impact

MJ Thorpy, AC Krieger - Sleep medicine, 2014 - Elsevier
Narcolepsy, a chronic neurologic condition resulting from dysregulation of the sleep–wake
cycle, usually has an onset at an early age. However, a long delay until diagnosis has been …

Clinical, polysomnographic and genome‐wide association analyses of narcolepsy with cataplexy: a European Narcolepsy Network study

G Luca, J Haba‐Rubio, Y Dauvilliers… - Journal of sleep …, 2013 - Wiley Online Library
The aim of this study was to describe the clinical and PSG characteristics of narcolepsy with
cataplexy and their genetic predisposition by using the retrospective patient database of the …

Comorbidities in a community sample of narcolepsy

A Cohen, J Mandrekar, EKS Louis, MH Silber… - Sleep medicine, 2018 - Elsevier
Study objective To assess comorbidities in a community-based cohort of narcolepsy.
Methods A 2000–2014 community-based narcolepsy cohort was identified in Olmsted …

[HTML][HTML] Clinical characteristics and burden of illness in pediatric patients with narcolepsy

G Plazzi, HM Clawges, JA Owens - Pediatric Neurology, 2018 - Elsevier
Background: Narcolepsy is a chronic and lifelong neurologic disorder with onset commonly
occurring in childhood or adolescence, and affecting approximately 0.025% to 0.05% of the …