Recent advances in the structural analysis of adenylation domains in natural product biosynthesis
Adenylation (A) domains catalyze the biosynthetic incorporation of acyl building blocks into
nonribosomal peptides and related natural products by selectively transferring acyl …
nonribosomal peptides and related natural products by selectively transferring acyl …
The chromodepsins–chemistry, biology and biosynthesis of a selective Gq inhibitor natural product family
C Hermes, GM König, M Crüsemann - Natural product reports, 2021 - pubs.rsc.org
Covering: up to April 2021 The bacterial cyclic depsipeptides FR900359 (FR) and YM-
254890 (YM) were shown to selectively inhibit Gαq proteins with high potency and selectivity …
254890 (YM) were shown to selectively inhibit Gαq proteins with high potency and selectivity …
Discovery of unusual dimeric piperazyl cyclopeptides encoded by a Lentzea flaviverrucosa DSM 44664 biosynthetic supercluster
Rare actinomycetes represent an underexploited source of new bioactive compounds. Here,
we report the use of a targeted metabologenomic approach to identify piperazyl compounds …
we report the use of a targeted metabologenomic approach to identify piperazyl compounds …
Biosynthesis of the corallorazines, a widespread class of antibiotic cyclic lipodipeptides
TM Dreckmann, L Fritz, CFF Kaiser… - RSC Chemical …, 2024 - pubs.rsc.org
Corallorazines are cyclic lipodipeptide natural products produced by the myxobacterium
Corallococcus coralloides B035. To decipher the basis of corallorazine biosynthesis, the …
Corallococcus coralloides B035. To decipher the basis of corallorazine biosynthesis, the …
[HTML][HTML] Functional Diversity and Engineering of the Adenylation Domains in Nonribosomal Peptide Synthetases
M Zhang, Z Peng, Z Huang, J Fang, X Li, X Qiu - Marine Drugs, 2024 - mdpi.com
Nonribosomal peptides (NRPs) are biosynthesized by nonribosomal peptide synthetases
(NRPSs) and are widely distributed in both terrestrial and marine organisms. Many NRPs …
(NRPSs) and are widely distributed in both terrestrial and marine organisms. Many NRPs …
Lessons learned in engineering interrupted adenylation domains when attempting to create trifunctional enzymes from three independent monofunctional ones
Interrupted adenylation (A) domains are fascinating examples of multifunctional enzymes.
They are found in nonribosomal peptide synthetases (NRPSs), which biosynthesize …
They are found in nonribosomal peptide synthetases (NRPSs), which biosynthesize …
(S)‐3‐aminopiperidine‐2,6‐dione is a biosynthetic intermediate of microbial blue pigment indigoidine
The biosynthetic investigations of microbial natural products continuously provide powerful
biocatalysts for the preparation of valuable chemicals. Practical methods for preparing (S)‐3 …
biocatalysts for the preparation of valuable chemicals. Practical methods for preparing (S)‐3 …