RecQ helicases are an important family of genome surveillance proteins conserved from
bacteria to humans. Each of the five human RecQ helicases plays critical roles in genome …

Eukaryotic genomes are highly complex and divided into linear chromosomes that require
end protection from unwarranted fusions, recombination, and degradation in order to …

Alternative lengthening of telomeres (ALT) is a telomerase-independent but recombination-
dependent pathway that maintains telomeres. Here, we describe an assay to visualize ALT …

Telomerase negative immortal cancer cells elongate telomeres through the Alternative
Lengthening of Telomeres (ALT) pathway. While sustained telomeric replicative stress is …

Telomeres protect chromosome ends through the interaction of telomeric repeats with
shelterin, a protein complex that represses DNA damage signaling and DNA repair …

The semiconservative replication of telomeres is facilitated by the shelterin component
TRF1. Without TRF1, replication forks stall in the telomeric repeats, leading to ATR kinase …

The discovery of telomeres dates back to the early 20th century. In humans, telomeres are
heterochromatic structures with tandem DNA repeats of 5′‐TTAGGG‐3′ at the …

Alternate DNA structures that deviate from B‐form double‐stranded DNA such as G‐
quadruplex (G4) DNA can be formed by sequences that are widely distributed throughout …

DNA damage repair response is an important biological process involved in maintaining the
fidelity of the genome in eukaryotes and prokaryotes. Several proteins that play a key role in …

Telomeres are dynamic nucleoprotein-DNA structures that cap and protect linear
chromosome ends. Several monogenic inherited diseases that display features of human …