Ischaemic conditioning and reperfusion injury

DJ Hausenloy, DM Yellon - Nature Reviews Cardiology, 2016 - nature.com
The 30-year anniversary of the discovery of'ischaemic preconditioning'is in 2016. This
endogenous phenomenon can paradoxically protect the heart from acute myocardial …

Extracellular vesicles in diagnostics and therapy of the ischaemic heart: Position Paper from the Working Group on Cellular Biology of the Heart of the European …

JPG Sluijter, SM Davidson, CM Boulanger… - Cardiovascular …, 2018 - academic.oup.com
Extracellular vesicles (EVs)—particularly exosomes and microvesicles (MVs)—are attracting
considerable interest in the cardiovascular field as the wide range of their functions is …

Remote ischemic preconditioning and outcomes of cardiac surgery

DJ Hausenloy, L Candilio, R Evans… - … England Journal of …, 2015 - Mass Medical Soc
Background Whether remote ischemic preconditioning (transient ischemia and reperfusion
of the arm) can improve clinical outcomes in patients undergoing coronary-artery bypass …

Remote ischemic conditioning

G Heusch, HE Bøtker, K Przyklenk, A Redington… - Journal of the American …, 2015 - jacc.org
In remote ischemic conditioning (RIC), brief, reversible episodes of ischemia with
reperfusion in one vascular bed, tissue, or organ confer a global protective phenotype and …

Ischaemic conditioning and targeting reperfusion injury: a 30 year voyage of discovery

DJ Hausenloy, JA Barrabes, HE Bøtker… - Basic research in …, 2016 - Springer
To commemorate the auspicious occasion of the 30th anniversary of IPC, leading pioneers
in the field of cardioprotection gathered in Barcelona in May 2016 to review and discuss the …

Critical issues for the translation of cardioprotection

G Heusch - Circulation research, 2017 - Am Heart Assoc
The translation from numerous successful animal experiments on cardioprotection beyond
that by reperfusion to clinical practice has to date been disappointing. Animal experiments …

Cardioprotection by remote ischemic conditioning and its signal transduction

P Kleinbongard, A Skyschally, G Heusch - Pflügers Archiv-European …, 2017 - Springer
Cardioprotective strategies aim to salvage myocardium from ischemia/reperfusion injury and
to reduce infarct size and its consequences. Different stimuli, acting at sites remote from the …

Time to give up on cardioprotection? A critical appraisal of clinical studies on ischemic pre-, post-, and remote conditioning

G Heusch, T Rassaf - Circulation research, 2016 - Am Heart Assoc
The mortality from acute myocardial infarction (AMI) remains significant, and the prevalence
of post-myocardial infarction heart failure is increasing. Therefore, cardioprotection beyond …

ESC Joint Working Groups on Cardiovascular Surgery and the Cellular Biology of the Heart Position Paper: Peri-operative myocardial injury and infarction in patients …

M Thielmann, V Sharma, N Al-Attar… - European heart …, 2017 - academic.oup.com
Coronary artery disease (CAD) is one of the leading causes of death and disability in
Europe and worldwide. For patients with multi-vessel CAD, coronary artery bypass graft …

Co‐morbidities and co‐medications as confounders of cardioprotection—Does it matter in the clinical setting?

P Kleinbongard, HE Bøtker, M Ovize… - British journal of …, 2020 - Wiley Online Library
The translation of cardioprotection from robust experimental evidence to beneficial clinical
outcome for patients suffering acute myocardial infarction or undergoing cardiovascular …