[HTML][HTML] Effect of metformin on stem cells: Molecular mechanism and clinical prospect

LL Jiang, L Liu - World journal of stem cells, 2020 - ncbi.nlm.nih.gov
Metformin is a first-line medication for type II diabetes. Numerous studies have shown that
metformin not only has hypoglycemic effects, but also modulates many physiological and …

Effects of metformin delivery via biomaterials on bone and dental tissue engineering

M Zhu, Z Zhao, HHK Xu, Z Dai, K Yu, L Xiao… - International Journal of …, 2022 - mdpi.com
Bone tissue engineering is a promising approach that uses seed-cell-scaffold drug delivery
systems to reconstruct bone defects caused by trauma, tumors, or other diseases (eg …

In vitro and in vivo investigation of PLA/PCL scaffold coated with metformin-loaded gelatin nanocarriers in regeneration of critical-sized bone defects

M Shahrezaee, M Salehi, S Keshtkari, A Oryan… - … , Biology and Medicine, 2018 - Elsevier
Large bone defects constitute a major challenge in bone tissue engineering and usually fail
to heal due to the incomplete differentiation of recruited mesenchymal stem cells (MSCs) …

Metformin promotes osteogenic differentiation and protects against oxidative stress-induced damage in periodontal ligament stem cells via activation of the Akt/Nrf2 …

L Jia, Y Xiong, W Zhang, X Ma, X Xu - Experimental Cell Research, 2020 - Elsevier
Periodontal ligament stem cell (PDLSC)-based tissue engineering is an important method
for regenerating lost bone in periodontitis. Maintaining or enhancing the osteogenic …

Metformin Decreases Reactive Oxygen Species, Enhances Osteogenic Properties of Adipose‐Derived Multipotent Mesenchymal Stem Cells In Vitro, and Increases Bone …

K Marycz, KA Tomaszewski, K Kornicka… - Oxidative medicine …, 2016 - Wiley Online Library
Due to its pleiotropic effects, the commonly used drug metformin has gained renewed
interest among medical researchers. While metformin is mainly used for the treatment of …

Equine metabolic syndrome affects viability, senescence, and stress factors of equine adipose‐derived mesenchymal stromal stem cells: new insight into EqASCs …

K Marycz, K Kornicka, K Basinska… - Oxidative Medicine and …, 2016 - Wiley Online Library
Currently, equine metabolic syndrome (EMS), an endocrine disease linked to insulin
resistance, affects an increasing number of horses. However, little is known about the effect …

Metformin‐induced MicroRNA‐34a‐3p downregulation alleviates senescence in human dental pulp stem cells by targeting CAB39 through the AMPK/mTOR signaling …

S Zhang, R Zhang, P Qiao, X Ma, R Lu… - Stem Cells …, 2021 - Wiley Online Library
Dental pulp stem cells (DPSCs) are ideal seed cells for the regeneration of dental tissues.
However, DPSC senescence restricts its clinical applications. Metformin (Met), a common …

Antioxidant and anti-senescence effect of metformin on mouse olfactory ensheathing cells (mOECs) may be associated with increased brain-derived neurotrophic …

A Śmieszek, Z Stręk, K Kornicka, J Grzesiak… - International journal of …, 2017 - mdpi.com
Metformin, the popular anti-diabetic drug was shown to exert multiple biological effects. The
most recent metformin gained attention as an agent that mobilizes endogenous progenitor …

MiR-21-5p regulates the dynamic of mitochondria network and rejuvenates the senile phenotype of bone marrow stromal cells (BMSCs) isolated from osteoporotic …

M Sikora, A Śmieszek, A Pielok, K Marycz - Stem cell research & therapy, 2023 - Springer
Background Progression of senile osteoporosis is associated with deteriorated regenerative
potential of bone marrow-derived mesenchymal stem/stromal cells (BMSCs). According to …

[HTML][HTML] Injectable periodontal ligament stem cell-metformin-calcium phosphate scaffold for bone regeneration and vascularization in rats

Y Sun, Z Zhao, Q Qiao, S Li, W Yu, X Guan… - Dental Materials, 2023 - Elsevier
Objectives Injectable and self-setting calcium phosphate cement scaffold (CPC) capable of
encapsulating and delivering stem cells and bioactive agents would be highly beneficial for …