Shedding light on the cell biology of extracellular vesicles

G Van Niel, G d'Angelo, G Raposo - Nature reviews Molecular cell …, 2018 - nature.com
Extracellular vesicles are a heterogeneous group of cell-derived membranous structures
comprising exosomes and microvesicles, which originate from the endosomal system or …

Microparticles: protagonists of a novel communication network for intercellular information exchange

SF Mause, C Weber - Circulation research, 2010 - Am Heart Assoc
Microparticles represent a heterogeneous population of vesicles with a diameter of 100 to
1000 nm that are released by budding of the plasma membrane and express antigens …

Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis

M Presta, P Dell'Era, S Mitola, E Moroni… - Cytokine & growth factor …, 2005 - Elsevier
Fibroblast growth factors (FGFs) are a family of heparin-binding growth factors. FGFs exert
their pro-angiogenic activity by interacting with various endothelial cell surface receptors …

Astrocyte-derived ATP induces vesicle shedding and IL-1β release from microglia

F Bianco, E Pravettoni, A Colombo… - The Journal of …, 2005 - journals.aai.org
ATP has been indicated as a primary factor in microglial response to brain injury and
inflammation. By acting on different purinergic receptors 2, ATP is known to induce …

The transcellular spread of cytosolic amyloids, prions, and prionoids

A Aguzzi, L Rajendran - Neuron, 2009 - cell.com
Recent reports indicate that a growing number of intracellular proteins are not only prone to
pathological aggregation but can also be released and" infect" neighboring cells. Therefore …

Intramyocardial fibroblast myocyte communication

R Kakkar, RT Lee - Circulation research, 2010 - Am Heart Assoc
Cardiac fibroblasts are emerging as key components of normal cardiac function, as well as
the response to stressors and injury. These most numerous cells of the heart interact with …

Microparticles in cancer

J Rak - Seminars in thrombosis and hemostasis, 2010 - thieme-connect.com
Microparticles (MP) are vesicular structures released from cells upon activation, malignant
transformation, stress, or death. MP may be derived from the plasma membrane (shed …

Cancer-derived small extracellular vesicles promote angiogenesis by heparin-bound, bevacizumab-insensitive VEGF, independent of vesicle uptake

SY Ko, WJ Lee, HA Kenny, LH Dang, LM Ellis… - Communications …, 2019 - nature.com
Cancer-derived small extracellular vesicles (sEVs) induce stromal cells to become
permissive for tumor growth. However, it is unclear whether this induction solely occurs …

The role of fibroblast growth factors and their receptors in prostate cancer

B Kwabi-Addo, M Ozen… - Endocrine-related cancer, 2004 - erc.bioscientifica.com
Prostate cancer is the most common malignancy in men in the USA and the second leading
cause of cancer deaths. Fibroblast growth factors (FGFs), including FGF1 (acidic FGF), FGF2 …

Unconventional secretory routes: direct protein export across the plasma membrane of mammalian cells

W Nickel - Traffic, 2005 - Wiley Online Library
The vast majority of extracellular proteins are exported from mammalian cells by the
endoplasmic reticulum/Golgi‐dependent secretory pathway. For poorly understood reasons …