Aptamers are nucleic acid analogues of antibodies with high affinity to different targets, such
as cells, viruses, proteins, inorganic materials, and coenzymes. Empirical approaches allow …

Nucleic acid aptamers are single-stranded DNA or RNA molecules identified to recognize
with high affinity specific targets including proteins, small molecules, ions, whole cells and …

Aptamers are functional single-stranded DNA or RNA oligonucleotides, selected in vitro by
SELEX (Systematic Evolution of Ligands by Exponential Enrichment), which can fold into …

First studies on thrombin-inhibiting DNA aptamers were reported in 1992, and since then a
large number of anticoagulant aptamers has been discovered. TBA–also named HD1, a 15 …

DNA G-quadruplexes (G4s) are known to be an integral part of the complex regulatory
systems in both normal and pathological cells. At the same time, the ability of G4s to impede …

Since aptamer and its in vitro selection process called SELEX were independently
described by Ellington and Gold in 1990, extensive research has been undertaken and …

The quest to improve the detection of biomolecules and cells in health and life sciences has
led to the discovery and characterization of various affinity bioprobes. Libraries of synthetic …

Non-canonical DNA structures are widely used for regulation of gene expression, in DNA
nanotechnology and for the development of new DNA-based sensors. I-motifs (iMs) are two …

DNA mismatch repair (MMR) plays a crucial role in the maintenance of genomic stability.
The main MMR protein, MutS, was recently shown to recognize the G-quadruplex (G4) DNA …

Aptamers are single stranded oligonucleotides, comparable to monoclonal antibodies
(mAbs) in selectivity and affinity and have significant strategic properties in design …