The past year has witnessed substantial advances in understanding the genetic basis of
many common phenotypes of biomedical importance. These advances have been the result …

Gastrointestinal (GI) cancers comprise a heterogeneous group of complex disorders that
affect different organs, including esophagus, stomach, gallbladder, liver, biliary tract …

Background Family history is a significant risk factor for prostate cancer, although the
molecular basis for this association is poorly understood. Linkage studies have implicated …

Background Single-nucleotide polymorphisms (SNPs) in five chromosomal regions—three
at 8q24 and one each at 17q12 and 17q24. 3—have been associated with prostate cancer …

Background Defective autophagy is thought to contribute to the pathogenesis of many
diseases, including cancer. Human plasmacytoma variant translocation 1 (PVT1) is an …

Previous studies have identified multiple loci on 8q24 associated with prostate cancer risk.
We performed a comprehensive analysis of SNP associations across 8q24 by genotyping …

Recent studies based on genome-wide association, linkage, and admixture scan analysis
have reported associations of various genetic variants in 8q24 with susceptibility to breast …

In Western countries, prostate cancer is the most prevalent cancer of men and one of the
leading causes of cancer-related death in men. Several genome-wide association studies …

GOLPH2 is coding the 73-kDa type II Golgi membrane antigen GOLPH2/GP73. Upregulation
of GOLPH2 mRNA has been recently reported in expression array analyses of prostate …

We carried out a fine-mapping study in the HNF1B gene at 17q12 in two study populations
and identified a second locus associated with prostate cancer risk,∼ 26 kb centromeric to …