Since the identification of the first SCN5A mutation associated with long QT syndrome in
1995, several mutations in this gene for the α subunit of the cardiac sodium channel have …

The pacemaker cells of the cardiac sinoatrial node (SAN) are essential for normal cardiac
automaticity. Dysfunction in cardiac pacemaking results in human sinoatrial node …

Cardiac Na+ channels encoded by the SCN5A gene are essential for initiating heart beats
and maintaining a regular heart rhythm. Mutations in these channels have recently been …

Rationale: Familial sick sinus syndrome (SSS) has been linked to loss-of-function mutations
of the SCN5A gene, which result in decreased inward Na+ current, I Na. However, the …

The voltage-gated sodium channel 1.5 (Nav1. 5), encoded by the SCN5A gene, is
responsible for the rising phase of the action potential of cardiomyocytes. The sodium …

Cardiac Diseases Caused by SCN5A Mutations. A prerequisite for a normal cardiac function
is a proper generation and propagation of electrical impulses. Contraction of the heart is …

Nav1. 5 is the predominant cardiac sodium channel subtype, encoded by the SCN5A gene,
which is involved in the initiation and conduction of action potentials throughout the heart …

Progressive cardiac conduction disease (PCCD) is often a primarily genetic disorder, with
clinical and genetic overlaps with other inherited cardiac and metabolic diseases. A number …

Background Mutations in the SCN5A gene, encoding the α subunit of the cardiac Na+
channel, Na v 1.5, can result in several life-threatening arrhythmias. Objective To …

Voltage-gated sodium channels produce fast depolarization, which is responsible for the
rising phase of the action potential in neurons, muscles and heart. These channels are very …