Transgenerational inheritance: how impacts to the epigenetic and genetic information of parents affect offspring health
BACKGROUND A defining feature of sexual reproduction is the transmission of genomic
information from both parents to the offspring. There is now compelling evidence that the …
information from both parents to the offspring. There is now compelling evidence that the …
[HTML][HTML] Novel genetic and epigenetic factors of importance for inter-individual differences in drug disposition, response and toxicity
Individuals differ substantially in their response to pharmacological treatment. Personalized
medicine aspires to embrace these inter-individual differences and customize therapy by …
medicine aspires to embrace these inter-individual differences and customize therapy by …
Extracellular histones as damage-associated molecular patterns in neuroinflammatory responses
CM Richards, SA McRae, AL Ranger… - Reviews in the …, 2023 - degruyter.com
The four core histones H2A, H2B, H3, H4, and the linker histone H1 primarily bind DNA and
regulate gene expression within the nucleus. Evidence collected mainly from the peripheral …
regulate gene expression within the nucleus. Evidence collected mainly from the peripheral …
Decoding the mechanism of hypertension through multiomics profiling
E Adua - Journal of Human Hypertension, 2023 - nature.com
Hypertension, characterised by a constant high blood pressure, is the primary risk factor for
multiple cardiovascular events and a major cause of death in adults. Excitingly, innovations …
multiple cardiovascular events and a major cause of death in adults. Excitingly, innovations …
The cGAS-STING pathway: post-translational modifications and functional implications in diseases
J Liu, K Rui, N Peng, H Luo, B Zhu, X Zuo, L Lu… - Cytokine & growth factor …, 2022 - Elsevier
Recent studies have illustrated the functional significance of DNA recognition in the
activation of innate immune responses among a variety of diseases. The cyclic GMP-AMP …
activation of innate immune responses among a variety of diseases. The cyclic GMP-AMP …
Epigenetic memory in development and disease: Unraveling the mechanism
S Thiagalingam - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2020 - Elsevier
Epigenetic memory is an essential process of life that governs the inheritance of predestined
functional characteristics of normal cells and the newly acquired properties of cells affected …
functional characteristics of normal cells and the newly acquired properties of cells affected …
Histone variant-specific post-translational modifications
FM Joseph, NL Young - Seminars in cell & developmental biology, 2023 - Elsevier
Post-translational modifications (PTMs) of histones play a key role in DNA-based processes
and contribute to cell differentiation and gene function by adding an extra layer of regulation …
and contribute to cell differentiation and gene function by adding an extra layer of regulation …
Reading cancer: chromatin readers as druggable targets for cancer treatment
The epigenetic machinery deputed to control histone post-translational modifications is
frequently dysregulated in cancer cells. With epigenetics being naturally reversible, it …
frequently dysregulated in cancer cells. With epigenetics being naturally reversible, it …
Capillary zone electrophoresis-tandem mass spectrometry as an alternative to liquid chromatography-tandem mass spectrometry for top-down proteomics of histones
Top-down proteomics (TDP) is an ideal approach for deciphering the histone code and it
routinely employs reversed-phase liquid chromatography (RPLC)-tandem mass …
routinely employs reversed-phase liquid chromatography (RPLC)-tandem mass …
[HTML][HTML] Nanoparticles and trained immunity: Glimpse into the future
Emerging evidences show that innate immune cells can display changes in their functional
programs after infection or vaccination, which lead to immunomodulation (increased or …
programs after infection or vaccination, which lead to immunomodulation (increased or …