Mechanisms of mitochondrial respiratory adaptation
CF Bennett, P Latorre-Muro, P Puigserver - Nature Reviews Molecular …, 2022 - nature.com
Mitochondrial energetic adaptations encompass a plethora of conserved processes that
maintain cell and organismal fitness and survival in the changing environment by adjusting …
maintain cell and organismal fitness and survival in the changing environment by adjusting …
Role of branched-chain amino acid metabolism in the pathogenesis of obesity and type 2 diabetes-related metabolic disturbances BCAA metabolism in type 2 …
F Vanweert, P Schrauwen, E Phielix - Nutrition & diabetes, 2022 - nature.com
Branched-chain amino acid (BCAA) catabolism has been considered to have an emerging
role in the pathogenesis of metabolic disturbances in obesity and type 2 diabetes (T2D) …
role in the pathogenesis of metabolic disturbances in obesity and type 2 diabetes (T2D) …
Endogenous renal adiponectin drives gluconeogenesis through enhancing pyruvate and fatty acid utilization
Adiponectin is a secretory protein, primarily produced in adipocytes. However, low but
detectable expression of adiponectin can be observed in cell types beyond adipocytes …
detectable expression of adiponectin can be observed in cell types beyond adipocytes …
An insight into brown/beige adipose tissue whitening, a metabolic complication of obesity with the multifactorial origin
Brown adipose tissue (BAT), a thermoregulatory organ known to promote energy
expenditure, has been extensively studied as a potential avenue to combat obesity …
expenditure, has been extensively studied as a potential avenue to combat obesity …
Downregulation of the kidney glucagon receptor, essential for renal function and systemic homeostasis, contributes to chronic kidney disease
The glucagon receptor (GCGR) in the kidney is expressed in nephron tubules. In humans
and animal models with chronic kidney disease, renal GCGR expression is reduced …
and animal models with chronic kidney disease, renal GCGR expression is reduced …
Limiting mitochondrial plasticity by targeting DRP1 induces metabolic reprogramming and reduces breast cancer brain metastases
Disseminated tumor cells with metabolic flexibility to utilize available nutrients in distal
organs persist, but the precise mechanisms that facilitate metabolic adaptations remain …
organs persist, but the precise mechanisms that facilitate metabolic adaptations remain …
The evolving view of thermogenic fat and its implications in cancer and metabolic diseases
X Yin, Y Chen, R Ruze, R Xu, J Song… - Signal Transduction and …, 2022 - nature.com
The incidence of metabolism-related diseases like obesity and type 2 diabetes mellitus has
reached pandemic levels worldwide and increased gradually. Most of them are listed on the …
reached pandemic levels worldwide and increased gradually. Most of them are listed on the …
Transcription factor NFYa controls cardiomyocyte metabolism and proliferation during mouse fetal heart development
Cardiomyocytes are highly metabolic cells responsible for generating the contractile force in
the heart. During fetal development and regeneration, these cells actively divide but lose …
the heart. During fetal development and regeneration, these cells actively divide but lose …
Role of distinct fat depots in metabolic regulation and pathological implications
B Sahu, O Tikoo, B Pati, U Senapati, NC Bal - Reviews of Physiology …, 2022 - Springer
People suffering from obesity and associated metabolic disorders including diabetes are
increasing exponentially around the world. Adipose tissue (AT) distribution and alteration in …
increasing exponentially around the world. Adipose tissue (AT) distribution and alteration in …
The RAF kinase inhibitor protein (RKIP): good as tumour suppressor, bad for the heart
J Abd Alla, U Quitterer - Cells, 2022 - mdpi.com
The RAF kinase inhibitor protein, RKIP, is a dual inhibitor of the RAF1 kinase and the G
protein-coupled receptor kinase 2, GRK2. By inhibition of the RAF1-MAPK (mitogen …
protein-coupled receptor kinase 2, GRK2. By inhibition of the RAF1-MAPK (mitogen …