The functions of Sertoli cells in spermatogenesis have attracted much more attention
recently. Normal spermatogenesis depends on Sertoli cells, mainly due to their influence on …

Sustaining and maintaining the intricate process of spermatogenesis is liable upon
hormones and growth factors acting through endocrine and paracrine pathways. The Sertoli …

Clinical efficacy of treatments against non-obstructive azoospermia (NOA), which affects 1%
of men, are currently limited by the incomplete understanding of NOA pathogenesis and …

Molecular events that regulate cellular biosynthesis of steroid hormones have been a topic
of intense research for more than half a century. It has been established that transport of …

Spermatogenesis is a complex and dynamic process which is precisely controlledby genetic
and epigenetic factors. With the development of new technologies (eg, single-cell RNA …

The gap junction protein connexin43 (CX43) plays a vital role in mammalian
spermatogenesis by allowing for direct cytoplasmic communication between neighbouring …

Sertoli cell death contributes to spermatogenesis impairment, which is associated with male
infertility. Testicular ischemia‑reperfusion (I/R) injury induces the cell death of germ cells and …

The blood-testis barrier (BTB) is found between adjacent Sertoli cells in the testis where it
creates a unique microenvironment for the development and maturation of meiotic and …

Very small embryonic-like stem cells (VSELs) exist among spermatogonial stem cells and
survive chemotherapy in both mice and human testes because of their relatively quiescent …

The loss of germ cells and spermatogenic failure in non-obstructive azoospermia are
believed to be the main causes of male infertility. Laboratory studies have used in vitro …