Lung cancer is the most frequent malignant neoplasm in most countries, and the main
cancer-related cause of mortality worldwide in both sexes combined. The geographic and …

An estimated 10–25% of lung cancers worldwide occur in never smokers, ie individuals
having smoked less than 100 cigarettes in their lifetime. Lung cancer in never smokers …

To identify new susceptibility loci to lung cancer among diverse populations, we performed
cross-ancestry genome-wide association studies in European, East Asian and African …

Migraine is a debilitating neurological disorder affecting around one in seven people
worldwide, but its molecular mechanisms remain poorly understood. There is some debate …

Germ-line genetic control of gene expression occurs via expression quantitative trait loci
(eQTLs). We present a large, exon-specific eQTL data set covering ten human brain regions …

We conducted imputation to the 1000 Genomes Project of four genome-wide association
studies of lung cancer in populations of European ancestry (11,348 cases and 15,861 …

A major goal in aging research is to improve health during aging. In the case of mice,
genetic manipulations that shorten or lengthen telomeres result, respectively, in decreased …

Telomerase (TERT) activation is a fundamental step in tumorigenesis. By maintaining
telomere length, telomerase relieves a main barrier on cellular lifespan, enabling limitless …

Genome-wide association studies (GWAS) were successful to identify genetic factors
robustly associated with lung cancer. This review aims to synthesize the literature in this field …

The Nobel Prize in Physiology or Medicine 2009 was recently awarded to three scientists for
their work on telomeres, which are repetitive DNA structures at the tips of chromosomes, and …